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APCS — IL2
Text-mined interactions from Literome
Chou et al., J Immunol 2005
(Berylliosis...) :
Our results demonstrate that in the
presence of
APCs , beryllium induced strong proliferation responses of BAL CD4 ( + ) T cells, production of superoptimal concentrations of secreted proinflammatory cytokines, IFN-gamma, TNF-alpha, and
IL-2 , and up-regulation of numerous T cell surface markers that would promote T-T Ag presentation
Kim et al., Ann N Y Acad Sci 2006
(Colitis, Ulcerative) :
Antigen presenting cells (APCs) lacking B7-1 or B7-2 stimulated T cell proliferation in vitro, but
caused suboptimal
IL-2 production, leading to decreased induction of CTLA-4
Cao et al., Zhonghua Xue Ye Xue Za Zhi 2009
:
Upon
stimulation with anti-CD3 epsilon and
APCs , the proliferative capacity of Foxp3 transduced T cells and the production of
IL-2 , IL-4, IL-10, IFN-gamma were significantly lower than those in control group ( P < 0.01 ) ; Foxp3 transduced T cells also significantly inhibited the proliferation of CD4 ( + ) CD25 ( - ) T cells
Keller et al., Clin Exp Allergy 2010
(Hypersensitivity, Delayed) :
We identified two mechanisms of T cell stimulation : some TCCs and the transfectant reacted to CM independent of uptake by APCs because
proliferation/IL-2 secretion occurred in the
presence of glutaraldehyde fixed
APCs , and intracellular calcium increased within seconds after drug addition
Ji et al., Immunol Cell Biol 2012
(Encephalomyelitis, Autoimmune, Experimental...) :
In vitro,
SAP suppressed the secretion of
interleukin-2 stimulated by P-selectin and blocked P-selectin binding to T cells
Meier et al., Eur J Biochem 1996
:
SAPKK-4 was the only
SAP kinase-1 activator
induced by
interleukin-1 or ultraviolet irradiation, while two SAP kinase-1 activators, SAPKK-1 and SAPKK-5, were induced by osmotic shock or anisomycin
Sad et al., J Immunol 1997
:
IL-2 synthesis was the most sensitive, as stimulation of IL-4 treated Tc1 cells with higher numbers of
APCs partially
restored IFN-gamma, TNF, and IL-10, but not
IL-2 , synthesis