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IGF1 — SOCS3
Text-mined interactions from Literome
Yadav et al., J Biol Chem 2005
:
Northern blot, semi-quantitative reverse transcription-PCR, and real time PCR experiments demonstrated that the JAK/STAT pathway also up-regulated
SOCS-3 mainly in
response to
IGF-1
Gupta et al., Exp Mol Pathol 2011
(Disease Models, Animal...) :
Western blot data revealed significantly high
SOCS-3 expression in PCASMCs in the
presence of either TNF-a or
IGF-1 ( 5-6 fold ) alone ... However, in the
presence of both TNF-a and
IGF-1 the
SOCS-3 expression was significantly decreased ( 4-5 fold )
Sinha et al., Cell Signal 2011
(Glioblastoma...) :
Importantly, TLR9 agonist reversed the
effect of
IGF-1 on CXCR4 and
SOCS3 expression ... While knockdown of HIF-1a abrogated
IGF-1 mediated increase in
SOCS3 it elevated IGF-1 induced decrease in CXCR4 levels
Al-Shanti et al., J Cell Biochem 2012
:
Inhibitory effects of IL-6 on
IGF-1 activity in skeletal myoblasts could be
mediated by the activation of
SOCS-3
van de Loo et al., Arthritis Rheum 2012
(Arthritis, Rheumatoid...) :
Overexpression of
SOCS-3 in bovine chondrocytes
reduced IL-1- and LPS induced nitric oxide production and
insulin-like growth factor 1-induced proteoglycan synthesis
Dhar et al., Am J Physiol Heart Circ Physiol 2013
:
Knockdown of STAT3 by small interfering RNA abolished
SOCS3 expression in
response to
IGF-1 ... Downregulation of
SOCS3 in the
presence of both TNF-a and
IGF-1 in hCASMCs is due to SOCS3 promoter hypermethylation involving STAT3-NFkBp65 interaction