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IGF1 — IL1A

Text-mined interactions from Literome

Hui et al., Ann Rheum Dis 2001 : Human articular chondrocytes and bovine nasal cartilage were cultured with and without IGF1 in the presence of IL1alpha or IL1alpha + OSM ... IGF1 can also down regulate IL1alpha or IL1alpha + OSM induced MMP-1, MMP-3, MMP-8, and MMP-13 mRNA expression in human articular chondrocytes and bovine chondrocytes
Wang et al., Arthritis Rheum 2003 : The effects of IGF-1 on the expression of IGF-1, IL-1alpha , and IL-1beta and their respective receptor systems, the aggrecan core protein, and CII were determined by flow cytometry
Linkhart et al., Endocrinology 1992 (Bone Resorption) : To determine whether increased or decreased IGF-I production in bone might mediate some of the effects of IL-1 on bone turnover, the effects of IL-1 alpha and IL-1 beta on IGF-I release from neonatal mouse calvaria in organ culture were examined ... IL-1 alpha and IL-1 beta stimulated resorption and increased the release of IGF-I into the medium during 6 days of culture ... These results suggest that the effects of IL-1 on resorption and release of IGF-I may be mediated in part by a prostaglandin dependent mechanism ... The results are consistent with the hypotheses that 1 ) IL-1 stimulates IGF-I production by bone cells, in part by PG-dependent mechanisms ; 2 ) the effects of IL-1 and PGs on bone formation and resorption may be mediated by locally induced secretion of IGF-I and other growth factors in bone
Broussard et al., J Immunol 2004 : In the absence of exogenous IGF-I , IL-1beta ( 1 ng/ml ) did not impair muscle cell development
Nawrat et al., Pharmacol Res 2005 : Instead, IL-1 was found to inhibit the expression of insulin-like growth factor-I receptor ( IGF-IR ) and MAP kinases-ERK1 and ERK2, while HA was shown to counteract this process
Shumate et al., Am J Physiol Gastrointest Liver Physiol 2005 (MAP Kinase Signaling System) : Therefore, an inhibitory effect of IL-1 on IGF-I and Spi 2.1 mRNA synthesis by GH represents the most likely mechanism for IL-1 mediated GH resistance
Porter et al., Tissue Eng 2007 : Here we investigate whether chondrocyte culture history influences the insulin-like growth factor-I (IGF-I) signaling system and its regulation by interleukin-1 (IL-1)
Buzzelli et al., J Trauma 2008 : Hepatic expression of growth hormone (GH)-inducible genes serine protease inhibitor ( Spi 2.1 ) and insulin-like growth factor (IGF)-I are inhibited by interleukin (IL)-1
Gude et al., Growth Horm IGF Res 2012 : The secretion of IGF-I is affected by GH, IL-1ß and TNF-a, whereas IGF-II is affected by TNF-a only
Wei et al., Spine (Phila Pa 1976) 2013 : The decreased gene expression of collagen I, collagen II, collagen IX, and IGF-1 induced by IL-1 was also reversed by U0126
Wang et al., Endocrinology 1995 : In conclusion, IL-1 beta inhibits IGF-I but increases IGFBP-3 expression in Leydig cells, and this may contribute to the inhibitory effects of IL-1 beta on Leydig cell steroidogenesis
Lazarus et al., Lymphokine Cytokine Res 1993 : Insulin-like growth factor-1 activity is inhibited by interleukin-1 alpha , tumor necrosis factor-alpha, and interleukin-6
Lang et al., Am J Physiol 1996 (Bacteremia...) : The purpose of the present investigation was to determine whether endogenously produced interleukin (IL)-1 mediates the changes in insulin-like growth factor (IGF) I and IGF binding proteins ( IGFBP ) induced by chronic abdominal sepsis in rats and to correlate the changes in the IGF system with the alternations in protein synthesis
Chevalier et al., Br J Rheumatol 1996 (Osteoarthritis) : IGF-I induced a 20-fold increase and IL-1 a 2-fold increase in IGFBP-3 release
Costantino et al., Endocrinology 1996 (Breast Neoplasms) : We examined the effects of IL-1 alpha and IL-1 beta on insulin and insulin-like growth factor I (IGF-I) stimulation of cell growth and found that both IL-1s inhibited anchorage dependent and independent growth of MCF-7 breast cancer cells
Thissen et al., Endocrinology 1997 : To determine whether cytokines can directly inhibit the production of IGF-I by the liver, we investigated the regulation of IGF-I gene expression by interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha ( 10 ng/ml ) in a model of rat primary cultured hepatocytes