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IFNG — XDH

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: XDH → IFNG (increases, IFNG Activity)
  Evidence: More importantly, XOR is secreted by the lactating mammary gland and the small intestine for an antimicrobial purpose [19, 36 and 37]. Although the mammary gland and milk provide immunological protection for the offspring, the intestine needs an intensive immune defense owing to its expansive epithelial surface, its multitude of villi and narrow invaginations, its exposure to dietary antigens and its proximity to the colon. XOR activity was detected in enterocytes and in the mucous of duodenum [...

Text-mined interactions from Literome

Dupont et al., J Clin Invest 1992 (Inflammation) : The results indicate that IFN-gamma is a potent inducer of XDH/XO activity in rat lung endothelial cells derived from both the microvasculature ( LMVC ) and the pulmonary artery ... In sum, IFN-gamma is a potent and biologically relevant inducer of XDH/XO expression ; the major site of upregulation occurs at the transcriptional level
Rinaldo et al., Am J Respir Cell Mol Biol 1994 : We studied the effect of IFN-gamma on XDH and XO in rat bone marrow macrophages, rat alveolar macrophages, and murine RAW cells ... We conclude that upon stimulation with IFN-gamma , inducible nitric oxide in macrophages leads to post-transcriptional inhibition of XDH/XO , possibly minimizing the potential for tissue injury from XO released from macrophages into the inflammatory milieu
Terada et al., J Interferon Res 1993 : Xanthine oxidase does not mediate the antiproliferative effects of interferon-gamma in human umbilical vein endothelial cells