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ASCL2 — CYP19A1

Text-mined interactions from Literome

Jiang et al., Mol Endocrinol 2000 (Choriocarcinoma) : In studies using BeWo, a human choriocarcinoma cell line, overexpression of Mash-2 also inhibited expression of cotransfected CYP19I.1 : hGH fusion gene constructs ... The findings that Mash-2 had no effect on the expression of a CYP19I.1 ( -42 ) : hGH fusion gene in primary cultures of human trophoblast and BeWo cells suggest that Mash-2 exerts its inhibitory effects directly or indirectly though CYP19I.1 5'-flanking sequences that lie between -42 and -125 bp
Jiang et al., Mol Cell Biol 2003 : Overexpression of Mash-2 prevents syncytiotrophoblast differentiation and induction of CYP19 expression ... Previously, we found that Mash-2 inhibited CYP19 promoter activity through sequences within a 350-bp region upstream and within placenta-specific exon I.1 containing three E boxes ( E1 at -325 bp, 5'-CACTTG-3 ' ; E2 at -58 bp, 5'-CACATG-3 ' ; and E3 at +26 bp, 5'-CACGTG-3 ' )