◀ Back to CCR7
CCR6 — CCR7
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Sato et al., J Immunol 2000
:
Stimulation of mature DCs with TGF-beta 1 also
enhanced TNF-alpha induced down-regulation of the expressions of CCR-1, CCR-3, CCR-5,
CCR-6 , and CXCR-4, and chemotaxis to their respective ligands, while this stimulation suppressed TNF-alpha induced expression of
CCR-7 and chemotactic migratory ability to MIP-3 beta
Iwasaki et al., J Exp Med 2000
:
These data support a distinct
role for
MIP-3alpha/CCR6 in recruitment of CD11b ( + ) DCs toward the mucosal surfaces and for
MIP-3beta/CCR7 in attraction of CD8alpha ( + ) DCs to the T cell regions
Dieu et al., J Exp Med 1998
:
Finally, detection by in situ hybridization of MIP-3alpha mRNA only within inflamed epithelial crypts of tonsils, and of MIP-3beta mRNA specifically in T cell-rich areas, suggests a
role for
MIP-3alpha/CCR6 in recruitment of immature DCs at site of injury and for
MIP-3beta/CCR7 in accumulation of antigen loaded mature DCs in T cell-rich areas