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CCL2 — PC

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Majkova et al., Toxicol Appl Pharmacol 2009 (Atherosclerosis...) : Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1 dependent ... We tested the hypothesis that intact caveolae are required for coplanar PCB77 induced up-regulation of monocyte chemoattractant protein-1 ( MCP-1 ), an endothelium derived chemokine that attracts monocytes into sub-endothelial space in early stages of the atherosclerosis development ... PCB77 increased MCP-1 levels in endothelial cells in a time- and concentration dependent manner ... Also, MCP-1 up-regulation by PCB77 was prevented by inhibiting p38 and c-Jun N-terminal kinase (JNK), but not ERK1/2, suggesting regulatory functions via p38 and JNK MAPK pathways ... Thus, our data demonstrate that coplanar PCB77 can induce MCP-1 expression by endothelial cells and that this effect is mediated by AhR, as well as p 38 and JNK MAPK pathways
Majkova et al., Toxicol Appl Pharmacol 2011 : Up-regulation of monocyte chemoattractant protein-1 ( MCP-1 ) by PCB77 was markedly reduced by oxDHA, but not by un-oxidized DHA ... Furthermore, sulforaphane prevented PCB77 induced MCP-1 expression, suggesting that activation of Nrf-2 mediates the observed protection against PCB77 toxicity