◀ Back to CASP3
CASP3 — PRKCD
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
PRKCD
→
CASP3
(increases, CASP3 Activity, PRKCD Activity)
Evidence: Caspase-dependent activation of kinases including PAK2, MEKK1, and PKCd also promotes cytoplasmic and nuclear apoptosis. Interestingly, MEKK1 activation enhances caspase activation, suggesting that kinases may amplify or initiate the caspase cascade.
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BioCarta hiv-1 nef: negative effector of fas and tnf:
Caspase 3/6 inactivated kinases (PTK2/PRKCD/RIPK1/MAP3K1/PAK2)
→
Caspase 3 (active) (CASP3)
(degradation, collaborate)
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NCI Pathway Database Syndecan-2-mediated signaling events:
Syndecan-2/PKC delta complex (SDC2-PRKCD)
→
Caspase 3 (CASP3)
(modification, activates)
Modrowski et al., Bone 2005*, Orosco et al., J Cell Biochem 2006*
Evidence: mutant phenotype, assay
-
NCI Pathway Database Syndecan-2-mediated signaling events:
Syndecan-2/PKC delta complex (SDC2-PRKCD)
→
Caspase 3 (tetramer) complex (CASP3)
(modification, activates)
Modrowski et al., Bone 2005*, Orosco et al., J Cell Biochem 2006*
Evidence: mutant phenotype, assay
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Reactome Reaction:
CASP3
→
PRKCD
(reaction)
Ghayur et al., J Exp Med 1996*
Text-mined interactions from Literome
Basu et al., Biochemistry 1999
:
Rottlerin, an inhibitor of
nPKCdelta ,
blocked caspase-3 activation and proteolytic cleavage of nPKCdelta by cDDP
Reyland et al., J Biol Chem 1999
:
Here we report that apoptosis results in the
caspase dependent cleavage of
protein kinase C-delta (PKCdelta) to a 40-kDa fragment, the appearance of which correlates with a 9-fold increase in PKCdelta activity
Koriyama et al., Cell Signal 1999
:
Proteolytic
activation of
protein kinase C delta and epsilon by
caspase-3 in U937 cells during chemotherapeutic agent induced apoptosis
Webb et al., Apoptosis 2000
(Inflammation) :
Spontaneous neutrophil apoptosis does not require Fas ligation, but is mediated by caspases 3, 8 and possibly
caspase 9 and also
involves activation of
protein kinase C-delta
Denning et al., Cell Death Differ 2002
:
The induction of apoptosis in human keratinocytes by UV radiation involves
caspase mediated cleavage and activation of
protein kinase C delta (PKCdelta)
Anantharam et al., J Neurosci 2002
:
Caspase-3 dependent proteolytic cleavage of
protein kinase Cdelta is essential for oxidative stress mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl
Mohamed et al., Biochem J 2002
(MAP Kinase Signaling System) :
Inhibition in HeLa cells of caspase function by pharmacological inhibitors or the expression of CrmA ( cytokine response modifier A ), a viral modifier protein, blocks TNF induced apoptosis or
caspase dependent
protein kinase Cdelta and poly ( ADP-ribose ) polymerase protein degradation
Kitazawa et al., Neuroscience 2003
(Parkinsonian Disorders) :
Dieldrin induces apoptosis by promoting
caspase-3 dependent proteolytic cleavage of
protein kinase Cdelta in dopaminergic cells : relevance to oxidative stress and dopaminergic degeneration
Kaul et al., Eur J Neurosci 2003
(Nerve Degeneration) :
Caspase-3 dependent proteolytic
activation of
protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+) induced apoptotic cell death in dopaminergic cells : relevance to oxidative stress in dopaminergic degeneration ... In the present study, we demonstrate that
caspase-3 mediated proteolytic
activation of
protein kinase C delta (PKC delta) is critical in MPP+ induced oxidative stress and apoptosis
Yang et al., Mol Cell Neurosci 2004
(Nerve Degeneration) :
Suppression of
caspase-3 dependent proteolytic activation of
protein kinase C delta by small interfering RNA prevents MPP+ induced dopaminergic degeneration ... Using RNA interference ( RNAi ), we demonstrate that
caspase-3 dependent proteolytic activation of
protein kinase Cdelta (PKCdelta) contributes to the degenerative process in dopaminergic neurons
Kitazawa et al., Neurotoxicology 2004
:
We also demonstrated that
protein kinase Cdelta (PKCdelta) , a member of a novel PKC family of proteins, is proteolytically
activated by
caspase-3 to mediate apoptotic cell death processes
Voss et al., J Biol Chem 2005
(Inflammation) :
Regulation of monocyte apoptosis by the
protein kinase Cdelta dependent phosphorylation of
caspase-3
Oh et al., Cancer Lett 2005
:
Caspase-3 dependent
protein kinase C delta activity is required for the progression of Ginsenoside-Rh2 induced apoptosis in SK-HEP-1 cells
Hanrott et al., Eur J Neurosci 2008
:
In an in vitro cellular model, we reported that 6-hydroxydopamine ( 6-OHDA ) induces apoptotic cell death via the induction of mitochondrial dysfunction, the
activation of
caspase 3 and the consequent proteolytic activation of the redox-sensitive kinase,
protein kinase C (PKC)delta , in PC12 cells
Kanthasamy et al., Molecular brain 2008
(Nerve Degeneration...) :
Environmental neurotoxin dieldrin induces apoptosis via
caspase-3 dependent proteolytic activation of
protein kinase C delta (PKCdelta) : Implications for neurodegeneration in Parkinson 's disease ... Furthermore, dieldrin caused the
caspase dependent proteolytic cleavage of
protein kinase C delta ( PKCd ) into 41 kDa catalytic and 38 kDa regulatory subunits in N27 cells as well as in brain slices
Cunningham et al., Endocrinology 2009
:
Androgens induce dopaminergic neurotoxicity via
caspase-3 dependent activation of
protein kinase Cdelta
Zhang et al., Toxicol Appl Pharmacol 2011
:
We previously demonstrated that
caspase-3 dependent proteolytic activation of
protein kinase C delta ( PKCd ) plays a key role in Mn-induced apoptotic cell death in dopaminergic neurons
Arango et al., Biochem Pharmacol 2012
:
Apigenin induced DNA damage was mediated by p38 and
protein kinase C-delta ( PKCd ), yet was
independent of reactive oxygen species or
caspase activity