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Bruey et al., J Biol Chem 2004
:
In gene transfer experiments PAN1 enhances caspase-1 activation and IL-1beta secretion in collaboration with ASC
Dorfleutner et al., Infect Immun 2007
(Inflammation) :
cPOP2 binds to ASC and PAN1, thereby blocking formation of cryopyrin and PAN1 containing inflammasomes, activation of caspase-1 , and subsequent processing and secretion of bioactive interleukin-1beta