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TGFB1 — VCAM1
Text-mined interactions from Literome
Park et al., Nephrol Dial Transplant 2000
:
The aim of this study was to determine the
effect of
TGF-beta(1) on the inflammatory cytokine induced expression of
vascular cell adhesion molecule-1 ( VCAM-1 ) in cultured human glomerular endothelial cells ...
TGF-beta(1) ( 10 ng/ml )
inhibited both IL-1beta- ( 5 ng/ml ) and TNF-alpha- ( 10 ng/ml ) induced expression of
VCAM-1 ( MFI : IL-1beta=90. 8+/- 17.6, IL-1beta+TGF-beta(1)=37.8+/-14.9, TNF-alpha=113.6+/- 12.4, TNF-alpha+TGF-beta(1)=64.3+/-13.8, mean+/-SD, n=3, P < 0.05 )
Hosokawa et al., Clin Exp Immunol 2006
:
However,
TGF-beta1 inhibited the
VCAM-1 expression induced by TNF-alpha or IL-4
Hosokawa et al., Clin Exp Immunol 2006
(Periodontitis) :
On the other hand, the TWEAK induced
VCAM-1 expression was
inhibited by
TGF-beta1
Aceves et al., Allergy 2010
(Eosinophilia...) :
In addition, we investigated whether corticosteroid therapy modulated vascular
activation ( expression of
VCAM-1 ; level of interstitial edema ),
TGFbeta(1) activation ( levels of TGFbeta(1), phosphorylated Smad2/3 ), and performed a pilot analysis of a polymorphism in the TGFbeta(1) promoter in relation to EE subjects who had reduced remodeling with budesonide therapy
Grünberg et al., Int J Mol Med 1998
:
We investigated the in vitro
effects of both prothymosin alpha1 ( Pro alpha1 ) and
transforming growth factor-beta1 ( TGF-beta1 ) on the adhesion of peripheral blood lymphocytes ( PBL ) and on the expression of the adhesion molecules, endothelial-leukocyte adhesion molecule-1 ( ELAM-1 ), intracellular adhesion molecule-1 ( ICAM-1 ) and
vascular cell adhesion molecule-1 ( VCAM-1 ) on human umbilical vein endothelial cells ( HUVECs ) ... Pro alpha1 in combination with TGF-beta1 showed no significant effects on ELAM-1 expression, but antagonized the
TGF-beta1 induced decrease of ICAM-1 and
VCAM-1 expression on activated HUVECs