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AKT1 — VCAM1
Text-mined interactions from Literome
Tung et al., Cell Signal 2007
:
In this study, we identified a
requirement for PDGFR,
PI3-K/Akt , p38 MAPK, JNK, and NF-kappaB in the regulation of
VCAM-1 expression by rat vascular smooth muscle cells ( VSMCs ) in response to viral infection
Lin et al., Toxicol Appl Pharmacol 2008
:
LPS stimulated Src, PYK2, EGFR, and Akt phosphorylation and
VCAM-1 expression were
attenuated by the inhibitors of Src ( PP1 ), EGFR ( AG1478 ), PI3-K ( LY294002 and wortmannin ), and Akt ( SH-5 ), respectively, or transfection with siRNAs of Src or
Akt and shRNA of p110 ... These results suggested that in HTSMCs,
Akt phosphorylation mediated through transactivation of Src/PYK2/EGFR promoted the transcriptional p300 activity and eventually
led to
VCAM-1 expression induced by LPS
Lee et al., Transplantation 2008
:
Signaling pathway analysis demonstrated that extracellular Ca2+ influx was critical to H2O2 mediated VCAM-1 expression ; however, protein kinase C, phospholipase D, and phosphatidylinositol-3
kinase/Akt activation were not
required for
VCAM-1 expression
Binion et al., Am J Physiol Gastrointest Liver Physiol 2009
:
We investigated the
effect of curcumin, phosphatidylinositol 3-kinase ( PI 3-kinase )
/protein kinase B ( Akt ), and mitogen activated protein kinase ( MAPK ) inhibitors on
VCAM-1 expression and function in HIMEC ... Tumor necrosis factor (TNF)-alpha/lipopolysaccharide (LPS) induced
VCAM-1 expression in HIMEC was
suppressed by Akt small interfering RNA, curcumin, and inhibitors of NF-kappaB ( SN-50 ), p38 MAPK ( SB-203580 ) and PI
3-kinase/Akt ( LY-294002 )
Wong et al., Arthritis Res Ther 2010
(Arthritis, Rheumatoid) :
Further investigations showed that the expression of ICAM-1,
VCAM-1 and chemokines stimulated by IL-27 was differentially
regulated by intracellular activation of phosphatidylinositol 3-OH
kinase-AKT , c-Jun amino-terminal kinase and Janus kinase pathways
Zhang et al., Scand J Immunol 2013
(MAP Kinase Signaling System) :
This is because knocking down
Akt1 or TAK1 by siRNA did not
reduce IL-17 induced activation of NF-?B and expression of
VCAM-1 , whereas knocking down NF-?B by siRNA markedly inhibited IL-17 mediated upregulation of VCAM-1 expression