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SOCS3 — TLR4

Text-mined interactions from Literome

Liu et al., Mol Immunol 2008 : SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-beta1/Smad3 signaling ... Suppressors of cytokine signaling 3 ( SOCS3 ) has been shown to be induced by TGF-beta1 in osteoclast/macrophage, while the reports on the role of SOCS3 in regulating TLR4 signaling were controversial
Deopurkar et al., Diabetes Care 2010 (Inflammation) : Indexes of inflammation including nuclear factor-kappaB (NF-kappaB) binding, and the expression of SOCS3 , tumor necrosis factor-alpha (TNF-alpha), and interleukin (IL)-1beta in MNCs, increased significantly after glucose and cream intake, but TLR-4 expression and plasma LPS concentrations increased only after cream intake
Zanin-Zhorov et al., Frontiers in immunology 2013 : Moreover, T cell TLR4 engagement by LPS leads to up-regulation of suppressor of cytokine signaling 3 expression and consequently down-regulates T cell chemotaxis