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ESR2 — STAT5B
Text-mined interactions from Literome
Frasor et al., Mol Endocrinol 2001
:
Interestingly, either Stat5a or Stat5b could stimulate ERalpha transcription while stimulation of
ERbeta occurred only in the
presence of
Stat5b ... These findings indicate that PRL stimulation of ER expression occurs at the level of transcription and that PRL regulation of ERalpha can be mediated by either Stat5a or Stat5b, while regulation of
ERbeta appears to be
mediated only by
Stat5b
Frasor et al., Trends Endocrinol Metab 2003
:
A single nucleotide difference between these two response elements is responsible for the observation that either Stat5a or Stat5b can stimulate Esr1 transcription, whereas only
Stat5b can
activate transcription of
Esr2