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PLD1 — SPHK1

Pathways - manually collected, often from reviews:

• KEGG Fc gamma R-mediated phagocytosis: PLD1/PLD2 → SPHK1/SPHK2 (protein-protein, activation)

Text-mined interactions from Literome

Melendez et al., J Biol Chem 2002 : Here we also show that SPHK1 activity depends on phospholipase D1 and that FcepsilonRI triggered mast cell degranulation depends primarily on the activation of both phospholipase D1 and SPHK1
Sethu et al., J Immunol 2008 (Calcium Signaling...) : Using antisense oligonucleotides to reduce specifically the expression of PLD isozymes showed PLD1 , but not PLD2, to be coupled to TNF-alpha signaling and that PLD1 is required to mediate receptor activation of sphingosine kinase and calcium transients