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MLST8 — PLD1
Text-mined interactions from Literome
Fang et al., Curr Biol 2003
:
PLD1 regulates
mTOR signaling and mediates Cdc42 activation of S6K1 ... Our observations reveal the
involvement of
PLD1 in
mTOR signaling and cell size control, and provide a molecular mechanism for Cdc42 activation of S6K1
Yoon et al., J Cell Sci 2008
:
Instead,
PLD1 positively
regulates mTOR signaling leading to the production of IGF2, an autocrine factor instrumental for the initiation of satellite cell differentiation ... Instead,
PLD1 positively
regulates mTOR signaling leading to the production of IGF2, an autocrine factor instrumental for the initiation of satellite cell differentiation
Suryawan et al., J Appl Physiol 2010
:
Our results suggest that the enhanced activation of
mTORC1 in muscle of neonatal pigs is in part
due to regulation by PRAS40,
PLD1 , and the Rag GTPases ... Our results suggest that the enhanced activation of
mTORC1 in muscle of neonatal pigs is in part
due to regulation by PRAS40,
PLD1 , and the Rag GTPases
Arous et al., Diabetologia 2011
:
Oleate mediated
mTORC1 activation
required phospholipase D activation, which produces phosphatidic acid and is known to render mTORC1 rapamycin resistant
Jaafar et al., J Biol Chem 2011
:
Vasopressin stimulation also induced phosphorylation of Akt on Ser-473 through
PLD1 dependent activation of
mTORC2 complex
Razmara et al., Cell communication and signaling : CCS 2013
:
In addition, PDGF-BB induced activation of
mTORC1 , as measured by phosphorylation of the downstream S6 protein, was
dependent on
phospholipase D ( PLD ) ...
mTORC1 is activated in a
PLD dependent manner and promotes phosphorylation of the S6 protein, whereas mTORC2, in concert with PLC? signaling, promotes Akt phosphorylation
Jaafar et al., Cell communication and signaling : CCS 2013
(Muscular Atrophy) :
These observations suggest that
PLD1 acts through the activation of both
mTORC1 and mTORC2 to induce positive trophic effects on muscle cells ... These observations suggest that
PLD1 acts through the activation of both mTORC1 and
mTORC2 to induce positive trophic effects on muscle cells