Ellerbroek et al., Cancer Res 1999
(Ovarian Neoplasms) :
Aggregation of beta1 integrins with immobilized 21C8 or P4C10 antibodies stimulated MMP dependent pro-MMP-2 activation and accumulation of a M ( r ) 43,000 form of membrane type 1 MMP (MT1-MMP) , a cell surface activator of pro-MMP-2, in cell extracts
Kazes et al., Kidney Int 1998
:
Matrix metalloprotease 2 (MMP2) is secreted in a latent inactive form ( pro-MMP2 ) that is activated on the cell surface by a membrane-type 1 MMP (MT1-MMP) in the presence of the tissue inhibitor of MMP ( TIMP2 )