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MAP2K1 — MAP3K8

Pathways - manually collected, often from reviews:

• KEGG Toll-like receptor signaling pathway: MAP3K8 → MAP2K1/MAP2K2 (protein-protein, phosphorylation)
• KEGG MAPK signaling pathway: MAP3K8 → MAP2K1 (protein-protein, phosphorylation)
• NCI Pathway Database Ras signaling in the CD4+ TCR pathway: COT (MAP3K8) → MEK1 (MAP2K1) (modification, activates) Salmeron et al., EMBO J 1996*
  Evidence: assay, other species
• Reactome Reaction: MAP3K8 → MAP2K1 (reaction)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAP2K1 — MAP3K8 (direct interaction, enzymatic study) Salmeron et al., EMBO J 1996*
• IRef Biogrid Interaction: MAP2K1 — MAP3K8 (direct interaction, enzymatic study) Eliopoulos et al., J Biol Chem 2006

Text-mined interactions from Literome

Hagemann et al., Oncogene 1999 : Wildtype and activated Cot phosphorylate and activate MEK-1 and SEK-1 in vitro
Tu et al., Cell Signal 2003 : They consist of a three-kinase module in which a mitogen activated protein kinase kinase kinase ( MAP3K ) activates a mitogen activated protein kinase kinase ( MAP2K ), which in turn activates MAPK
Huang et al., Biochem Biophys Res Commun 2003 : MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a mitogen activated protein kinase kinase ( MAP2K ), which in turn activates a mitogen activated protein kinase ( MAPK )
López-Pelaéz et al., Mol Biol Cell 2012 (Inflammation...) : Cot/tpl2 is the only MAP3K that activates MKK1/2-Erk1/2 in Toll-like receptor activated macrophages
Roget et al., Mol Cell Biol 2012 : LPS stimulation of TPL-2 MEK-1/2 kinase activity requires TPL-2 release from p105
Sanz-Garcia et al., J Biol Chem 2013 (Drug-Induced Liver Injury...) : Cot/tpl2 ( MAP3K8 ) activates MKK1/2-Erk1/2 following stimulation of the Toll-like/IL-1 receptor superfamily
Tsatsanis et al., Oncogene 1998 (Lymphoma, T-Cell) : Since the activation of NFAT is MAPK dependent these findings suggested that the activation of MAPK by Tpl-2 is either independent or only partially dependent on MEK1 and MEK2