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FOXM1 — MAP2K1

Text-mined interactions from Literome

Ma et al., J Cell Sci 2005 (MAP Kinase Signaling System) : In transient reporter assays, constitutively active MEK1 enhances the transactivating effect of FOXM1c, but not FOXM1b , on the cyclin B1 promoter ... Importantly, inhibition of Raf/MEK/MAPK signaling by U0126 led to suppression of FOXM1 target gene expression and delayed progression through G2/M, verifying the functional relevance of FOXM1 activation by MEK1
Lam et al., Frontiers in oncology 2013 : Importantly, the MEK1 activation of FOXM1c was associated with proteolytic processing to generate short forms that might represent constitutively active forms missing the N-terminal inhibitory domain ; in contrast, the proteolytic processing of FOXM1b did not require MEK1 activation