◀ Back to IGF2
ICR5 — IGF2
Text-mined interactions from Literome
Szabó et al., Curr Biol 2000
:
Parent-of-origin-specific expression of the mouse
insulin-like growth factor 2 (Igf2) gene and the closely linked H19 gene are
regulated by an intervening 2 kb
imprinting control region ( ICR ) , which displays parentspecific differential DNA methylation [ 1 ] [ 2 ]
Banerjee et al., TheScientificWorldJournal 2001
:
On paternal inheritance, the methylated ICR silences the H19 gene and indirectly facilitates transcription from the distant Igf2 promoter, whereas on the maternal chromosome the unmethylated
ICR , together with enhancers,
activates transcription of the H19 gene and thereby contributes to the repression of
Igf2
Szabó et al., Mol Cell Biol 2004
:
A approximately 2.4-kb
imprinting control region ( ICR ) regulates somatic monoallelic expression of the
Igf2 and H19 genes ... In somatic cells, the hypomethylated maternally inherited
ICR binds the insulator protein CTCF at four sites and
blocks activity of the proximal
Igf2 promoter by insulating it from its distal enhancers
Szabó et al., Mol Cell Biol 2004
:
Parent-of-origin-specific expression of the mouse
insulin-like growth factor 2 gene (Igf2) and the closely linked H19 gene located on distal chromosome 7 is
regulated by a 2.4-kb
imprinting control region ( ICR ) located upstream of the H19 gene
Katz et al., Mol Cell Biol 2005
:
The imprinted expression of the H19 and
Igf2 genes in the mouse is
controlled by an
imprinting control center ( ICR ) whose activity is regulated by parent-of-origin differences in methylation
Szabó et al., Cytogenet Genome Res 2006
:
The hypomethylated maternally inherited
ICR binds the insulator protein CTCF at four sites, and
blocks activity of the proximal
Igf2 promoter by insulating it from the shared distal enhancers
Kurukuti et al., Proc Natl Acad Sci U S A 2006
:
CTCF binding in the maternal
ICR regulates its interaction with matrix attachment region ( MAR ) 3 and DMR1 at
Igf2 , thus forming a tight loop around the maternal Igf2 locus, which may contribute to its silencing
Han et al., Mol Cell Biol 2008
:
A paternally methylated
imprinting control region ( ICR ) directs allele-specific expression of the imprinted H19 and
Igf2 genes
Ideraabdullah et al., Dev Biol 2011
:
Like most imprinted genes, H19 and
Igf2 are
regulated by a differentially methylated
imprinting control region ( ICR )