◀ Back to E2F7
CDC6 — E2F7
Pathways - manually collected, often from reviews:
-
NCI Pathway Database E2F transcription factor network:
E2F7 (E2F7)
→
CDC6 (CDC6)
(transcription, inhibits)
Wu et al., Nature 2001, Di Stefano et al., EMBO J 2003, Christensen et al., Nucleic Acids Res 2005, Yan et al., Proc Natl Acad Sci U S A 1998, Hateboer et al., Mol Cell Biol 1998, Ohtani et al., Oncogene 1998
Evidence: mutant phenotype, reporter gene, physical interaction
Text-mined interactions from Literome
Yan et al., Proc Natl Acad Sci U S A 1998
:
Cdc6 is
regulated by
E2F and is essential for DNA replication in mammalian cells
Hateboer et al., Mol Cell Biol 1998
:
Furthermore,
E2F is
sufficient to induce expression of the endogenous
CDC6 gene even in the absence of de novo protein synthesis
Ohtani et al., Oncogene 1998
:
Expression of endogenous
Cdc6 was
induced by exogenous expression of
E2F ... Therefore, we concluded that the growth regulated expression of mammalian
Cdc6 was
mediated by
E2F