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CDKN1A — NFKB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Javelaud et al., Oncogene 2000
(Sarcoma, Ewing) :
Induction of
p21Waf1/Cip1 by TNFalpha
requires NF-kappaB activity and antagonizes apoptosis in Ewing tumor cells
Seitz et al., Cancer Res 2000
(Hyperplasia) :
An active NF-kappaB subunit expressed in the epidermis of p21 ( CiP1-/- mice, however, displays only partial growth-inhibitory effects, suggesting that full
NF-kappaB growth inhibition is only partially
p21 ( Cip1 )
dependent in this setting
Pennington et al., Mol Cell Biol 2001
:
IkappaB kinase dependent chronic activation of
NF-kappaB is
necessary for
p21 ( WAF1/Cip1 ) inhibition of differentiation induced apoptosis of monocytes
Basile et al., Mol Cancer Res 2003
:
NF-kappaB mediated induction of
p21 ( Cip1/Waf1 ) by tumor necrosis factor alpha induces growth arrest and cytoprotection in normal human keratinocytes
Hinata et al., Oncogene 2003
(Inflammation) :
In keratinocytes, but not in fibroblasts,
NF-kappa B induced
p21 ( CIP1 ), which was sufficient to inhibit growth of both cell types
Dai et al., Cell cycle (Georgetown, Tex.) 2003
:
Finally, the NF-kappaB inhibitor CAPE antagonized NaB- and PMA related
NF-kappaB DNA binding as well as
induction of
p21CIP1 ... Together, these findings suggest that
NF-kappaB plays an important functional role in mediating NaB induced
p21CIP1 induction, G1 arrest, and maturation in human myelomonocytic leukemia cells, and that disruption of the NF-kappaB pathway causes cells to engage an alternative, apoptotic program
Chen et al., J Cell Biochem 2004
(Carcinoma, Papillary...) :
Furthermore, we demonstrated that increased levels of HO-1 and p21 expression are associated with an increase in the activity of NF-kappaB and that inhibiting
NF-kappaB leads to a block in the induction of HO-1 and
p21
Nasr et al., Oncogene 2005
(Leukemia-Lymphoma, Adult T-Cell...) :
PS-341 treatment of these cells stabilized IkappaBalpha, IkappaBbeta, IkappaBvarepsilon,
p21 , p27 and p53 proteins and selectively
inhibited Rel-A DNA binding
NF-kappaB complexes
Akita et al., Virology 2005
:
Previously, we reported that
p21WAF1 stimulated Tax dependent
NF-kappaB activation which influences a variety of cellular processes, including proliferation, differentiation, and apoptosis ... Here, we demonstrate that
p21WAF1 affects Tax dependent
NF-kappaB signaling by inducing p100/52, an NF-kappaB related protein
Savickiene et al., Int J Biochem Cell Biol 2005
(Leukemia) :
p21 ( Waf1/Cip1 ) and FasL gene
activation via Sp1 and
NFkappaB is required for leukemia cell survival but not for cell death induced by diverse stimuli
Chang et al., Mol Cancer Res 2006
(Leukemia, T-Cell) :
Here, we provide evidence that sequential
NF-kappaB activating signals
induce heightened NF-kappaB DNA binding and
p21 ( waf1/cip1 ) induction in CEM and additional T leukemic cell lines ... Subsequent stimulation of these cells with an anticancer agent, etoposide, results in augmented
NF-kappaB dependent
p21 ( waf1/cip1 ) induction and increased chemoresistance of the leukemia cells
Kumar et al., Molecular cancer 2007
(Brain Neoplasms...) :
Our data using IkappaBalpha mutant LN-18 cells and PI3K/Akt inhibitor-LY294002 revealed that the expression of
p21 is
regulated by
NF-kappaB ... Our findings provide evidence that TNF-alpha induced
p21 might be
regulated by
NF-kappaB or p53 independently
Lee et al., American journal of physiology. Renal physiology 2008
:
Consequently, the inhibition of Ca ( 2+ ), PKC, EGFR, p44/42 MAPKs, or
NF-kappaB blocked the BSA induced increases in cyclin D1, cyclin dependent kinase (CDK)4, cyclin E, or CDK2 and
restored the BSA induced inhibition of
p21 ( WAF/Cip1 ) and p27 ( Kip1 ) expression
Shankar et al., Molecular cancer 2008
(Neoplasm Metastasis...) :
In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak,
p21/WAF1 , and p27/KIP1, and
inhibited the activation of
NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL
Orr et al., Circ Res 2008
:
p21 activated kinase signaling
regulates oxidant dependent
NF-kappa B activation by flow
Ji et al., Anticancer Drugs 2009
(Lung Neoplasms) :
Consistent with our earlier observation that
p21 is induced in an
NFkappaB/p65 dependent manner, we conclude that p21 plays an important role in mediating cell growth inhibition by gefitinib
Diaz-Meco et al., Mol Cell Biol 1993
:
It has recently been demonstrated in the model system of Xenopus laevis oocytes that the PMA-insensitive PKC isotype, zeta PKC, is a required step in the activation of
NF-kappa B in
response to ras
p21
Dominguez et al., Mol Cell Biol 1993
:
In this report, we present evidence that in oocytes from Xenopus laevis, ( i ) ras p21- and phospholipase C (PLC) mediated phosphatidylcholine ( PC ) hydrolysis activates NF-kappa B and ( ii ) protein kinase C zeta subspecies is involved in the activation of
NF-kappa B in
response to insulin/ras
p21/PC-PLC