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CDKN1A — EP300

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CDKN1A → EP300 (increases)
  Evidence: In addition, p300-deficient (p300(-)) cells fail to undergo G(1)/S arrest after UV irradiation. These abnormalities are associated with prolongation of p53 stability, reduced p53-acetylation, blunting of MDM2 activation, failure to transactivate p21, and a disproportionate increase in PUMA levels.
• BioCarta cell cycle: g2/m checkpoint: p300 (EP300) → p21 (CDKN1A) (transcription, activates)
• BioCarta hypoxia and p53 in the cardiovascular system: TFIID/RPA/JNK/p300/p53 complex (TAF1-RPA1-MAPK8-EP300-TP53) → p21 (CDKN1A) (transcription, activates)
• NCI Pathway Database Validated transcriptional targets of TAp63 isoforms: TAp63g (tetramer)/p300 complex (TP63-EP300) → p21CIP1 (CDKN1A) (transcription, activates) MacPartlin et al., J Biol Chem 2005, Guo et al., Nat Cell Biol 2009*, Heyne et al., Nucleic Acids Res 2010*, Deutsch et al., Cell 2011*
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Validated transcriptional targets of TAp63 isoforms: TAp63g (tetramer)/p300 complex (TP63-EP300) → p21CIP1 (CDKN1A) (transcription, activates) MacPartlin et al., J Biol Chem 2005, Kommagani et al., Oncogene 2006*, Guo et al., Nat Cell Biol 2009*, Deutsch et al., Cell 2011*
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EP300 — CDKN1A (physical association, affinity chromatography technology) Cazzalini et al., Nucleic Acids Res 2008*
• IRef Biogrid Interaction: EP300 — CDKN1A (direct interaction, pull down) Cazzalini et al., Nucleic Acids Res 2008*
• IRef Innatedb Interaction: EP300 — CDKN1A (unknown, -) Smith et al., Proc Natl Acad Sci U S A 2004
• IRef Innatedb Interaction: EP300 — CDKN1A (unknown, -) Dornan et al., Mol Cell Biol 2004*
• IRef Innatedb Interaction: Complex of EP300-CDKN1A-CDKN1A (unknown, -) Lee et al., Oncogene 2012*
• IRef Intact Interaction: Complex of 30 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013

Text-mined interactions from Literome

Cazzalini et al., Nucleic Acids Res 2008 : These results indicate that p21 is required during DNA repair to regulate p300 HAT activity by disrupting its interaction with PCNA
Yuan et al., American journal of physiology. Renal physiology 2013 (Diabetic Nephropathies) : Thus TGF-ß1 induced PAI-1 and p21 expression involves interaction of p300/CBP with Smads and Sp1, and increased promoter access via p300/CBP induced H3K9/14Ac