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CDK5 — MAP2K1

Pathways - manually collected, often from reviews:

• BioCarta phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway: P35/CDK5 complex (CDK5R1-CDK5) → MEK1 (MAP2K1) (modification, activates)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: CDK5 — MAP2K1 (in vivo) Sharma et al., J Biol Chem 2002*
• IRef Hprd Interaction: CDK5 — MAP2K1 (in vitro) Sharma et al., J Biol Chem 2002*

Text-mined interactions from Literome

Kivinen et al., Oncogene 1999 (MAP Kinase Signaling System) : p21Cip1/Waf1 cyclin dependent kinase inhibitor ( p21 ) is inducible by Raf and mitogen activated protein kinase kinase ( MAPKK ), but the level of regulation is unknown
Pareek et al., Cell cycle (Georgetown, Tex.) 2006 (Calcium Signaling...) : Here, we report that Cdk5 regulates mitogen activated protein kinase kinase1/2 ( MEK1/2 ) activity through a negative feedback loop during the peripheral inflammatory response