◀ Back to CD44
CD44 — MMP2
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
CD44
→
MMP2
(reaction)
Ahmed et al., Carcinogenesis 2002*, Samanna et al., Exp Cell Res 2006*, Toole et al., Curr Opin Cell Biol 1990*
-
Reactome Reaction:
CD44
→
MMP2
(direct_complex)
Ahmed et al., Carcinogenesis 2002*, Samanna et al., Exp Cell Res 2006*, Toole et al., Curr Opin Cell Biol 1990*
Text-mined interactions from Literome
Zhang et al., Cancer Res 2002
(Carcinoma, Small Cell...) :
Hyaluronan-CD44s signaling
regulates matrix metalloproteinase-2 secretion in a human lung carcinoma cell line QG90 ... We found that expression of antisense CD44s in QG90 cells substantially inhibited the HA-dependent secretion of MMP-2, whereas overexpression of full-length
CD44s augmented the HA-dependent secretion of
MMP-2 ... Taken together,
HA-CD44s signaling
plays a key role in the HA-dependent secretion of
MMP-2 and, hence, in the invasiveness of QG90 cells
Huh et al., J Cell Biochem 2007
:
Both
CD44v6 and its ectodomain cleavage products were detected from ED 5 to ED 14, and a broad-spectrum
MMP inhibitor
blocked ectodomain cleavage in cultured stromal cells
Campo et al., Biochim Biophys Acta 2009
:
HA treatment produced different effects : low MW HA up-regulated
CD44 expression, increased PKCdelta and PKCepsilon levels, and
enhanced inflammation in untreated chondrocytes ; while in PMA treated cells it increased CD44, PKCdelta, PKCepsilon, NF-kB, TNF-alpha, IL-1beta,
MMP-13 , and iNOS expression and enhanced the effects of PMA ; medium MW HA did not exert action ; high MW HA had no effect on untreated chondrocytes ; however, it reduced PKCdelta, PKCepsilon, NF-kB activation and inflammation in PMA stimulated cells
Fang et al., BMC cancer 2011
(Breast Neoplasms...) :
Erk and P-Erk were investigated by Western blotting to approach the molecular mechanisms of
MMP-2 and MMP-9 expression
regulated by the
CD44st
Takahashi et al., Int J Cancer 1999
(Melanoma...) :
Involvement of
CD44 in
matrix metalloproteinase-2 regulation in human melanoma cells ...
CD44 binding by F10-44-2 MAb
results in induction of
MMP-2 expression, which is associated with enhanced cell migration and invasion