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ANGPT2 — FGFR3
Pathways - manually collected, often from reviews:
-
WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16
→
FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK
(activation)
Text-mined interactions from Literome
Winter et al., Oncogene 2007
:
Reporter assays confirmed that the
Ang-2 promoter was
regulated by FGFR1 signaling and a small molecule inhibitor of
FGFR activity, PD173074, could abrogate this response
Kawada et al., Am J Physiol Heart Circ Physiol 2007
:
In contrast, in a group with local administration of losartan ( 10 mM, n = 6 ) through the dialysis probe,
ANG II inhibited the stimulation induced
ACh release ( 8.0 +/- 0.8 vs. 5.8 +/- 1.0 nM, P < 0.05 )
Tota et al., Psychopharmacologia 2013
(Synaptic Transmission) :
This study suggests that
Ang II , via the AT1 receptor,
affects spatial memory formation, CBF, and
ACh level while AT2 receptor has no significant role