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AHSA1 — TAB1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ge et al., J Biol Chem 2003
:
Inhibition of
TAB1beta expression with RNA interference in MDA231 breast cancer cells
resulted in the reduction of basal activity of
p38alpha and invasiveness of MDA231 cells, suggesting that TauAlphaBeta1beta is involved in regulating p38alpha activity in physiological conditions
Singhirunnusorn et al., J Biol Chem 2005
:
Furthermore, SB203580 and
p38alpha small interfering RNA
enhanced TNF-alpha induced Thr-187 phosphorylation as well as
TAK1 kinase activity, indicating that the phosphorylation is affected by p38alpha/TAB1/TAB2 mediated feedback control of TAK1
Lu et al., J Biol Chem 2006
(MAP Kinase Signaling System) :
In contrast to MKK3 induced p38 kinase downstream effects,
TAB-1 induced
p38 kinase activation does not induce expression of pro-inflammatory genes, cardiac marker gene expression, or changes in cellular morphology ... In contrast to MKK3 induced p38 kinase downstream effects,
TAB-1 induced
p38 kinase activation does not induce expression of pro-inflammatory genes, cardiac marker gene expression, or changes in cellular morphology ... These data suggest that
TAB-1 can
mediate MKK independent
p38 kinase activation while negatively modulating MKK dependent p38 function ... Our study not only redefines the functional
role of
TAB-1 in
p38 kinase mediated signaling pathways but also provides the first evidence that intracellular localization of p38 kinase and complex interaction dictates its downstream effects