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AHSA1 — IL1A

Text-mined interactions from Literome

Sheng et al., Neurochem Int 2001 (Alzheimer Disease) : This, together with findings showing that IL-1 activates MAPK-p38 in vitro and is markedly overexpressed in Alzheimer brain, suggest a role for IL-1 induced MAPK-p38 activation in the genesis of neurofibrillary pathology in Alzheimer 's disease
Thomas et al., Biochem J 2002 : Interestingly, IL-1beta induced p38 MAPK activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells
Vela et al., Mol Cell Neurosci 2002 : Regarding intracellular signaling, IL-1beta activated the p38 mitogen activated protein kinase ( MAPK ) but not the p42/p44 MAPK and, when combined with growth factors, intensified p38 activation but inhibited the growth-factor induced p42/p44 activation
Kim et al., Mol Pharmacol 2002 : These results indicate that in human pulmonary epithelial cells, IL-1beta activates ERK or p38 to induce COX-2 production, which in turn induces MUC2 and MUC5AC production
Lee et al., J Biomed Sci 2003 (Liver Cirrhosis) : Differential role of p38 in IL-1alpha induction of MMP-9 and MMP-13 in an established liver myofibroblast cell line
Huang et al., Nat Immunol 2004 : Furthermore, MEKK3 is crucial for IL-1- and LPS induced activation of NF-kappaB and JNK-p38 but not ERK, indicating that MAPKs are differentially activated during IL-1R-TLR4 signaling
Kim et al., J Neurochem 2004 : IL-1 or IL-1/IFNbeta induced RANTES/CCL5 expression was inhibited by the super-repressor IkappaBalpha or inhibitors of p38 or c-Jun N-terminal kinase (JNK) MAPKs ( mitogen activated protein kinases ), but not by extracellular signal regulated kinases ( ERK ) inhibitors
Farivar et al., J Heart Lung Transplant 2004 (Bronchiolitis Obliterans...) : p38 regulates the expression of the cytokines tumor necrosis ( TNF)-alpha and interleukin (IL)-1beta , 2 mediators involved in the development of OB in a tracheal transplant model
Wang et al., Am J Physiol Lung Cell Mol Physiol 2005 : Consistently, IL-1beta stimulated phosphorylation of p42/p44 MAPK, p38 , and JNK was attenuated by pretreatment with U0126, SB-202190, or SP-600125, respectively
Størling et al., Diabetologia 2005 : Likewise, IL-1beta induced JNK and p38 activities were lower in iNOS ( -/- ) mouse islets than in wild-type islets
Zhang et al., Molecular vision 2009 : Furthermore, BOL-303242-X inhibited IL-1ss induced decreases in IkappaB-alpha levels, as well as IL-1ss induced phosphorylation of NFkappaB, p38 , and c-Jun-N-terminal kinase (JNK) MAPKs in HCEpiCs
Tanabe et al., Journal of neuroinflammation 2011 : We previously reported that interleukin (IL)-1ß stimulates IL-6 synthesis from rat C6 glioma cells and that IL-1ß induces phosphorylation of inhibitory kappa B ( I?B ), p38 mitogen activated protein ( MAP ) kinase, stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK), extracellular signal regulated kinase 1/2, and signal transducer and activator of transcription ( STAT ) 3
Turner-Brannen et al., Arthritis Res Ther 2011 (Inflammation) : With various immunochemical assays, it was further demonstrated that IL-1ß induced NF-?B, JNK, and p38 mitogen activated protein kinase ( MAPK ) activations were significantly suppressed by IDR-1002
Huang et al., J Neurosci 2011 : In astrocytes, IL-1ß induced both the p38 MAPK and NF-?B ( nuclear factor ?B ) pathways regulating inflammatory responses, however in hippocampal neurons IL-1ß activated p38 but not NF-?B
Drube et al., Eur J Pharmacol 2012 : Treatment of HMC-cells with the c-Kit inhibitor STI571 blocked the IL-1ß induced activation of Erk1/2 and JNK1/2 but not p38 and NF?B
Akhtar et al., Ann Rheum Dis 2012 (Osteoarthritis) : IL-1ß induced activation of p38-MAPK correlates inversely with miR199a* expression levels
Jagielska et al., Arterioscler Thromb Vasc Biol 2012 (Disease Models, Animal...) : Accordingly, cellular cholesterol depletion ( cyclodextrin ) and silencing of caveolin-1 ( small interfering RNA ) inhibited IL-1ß induced activation of p38-MAPK and MK2, as well as IL-1ß induced tube formation and migration
Simões et al., Journal of neuroinflammation 2012 (MAP Kinase Signaling System) : The effect of SCH58261 on the IL-1ß induced phosphorylation of the mitogen activated protein kinases ( MAPKs ) c-Jun N-terminal kinase (JNK) and p38 was evaluated by western blotting and immunocytochemistry ... IL-1ß ( 10 to 100 ng/ml ) enhanced both JNK and p38 phosphorylation, and these effects were prevented by the IL-1 type 1 receptor antagonist IL-1Ra ( 5 µg/ml ), in accordance with the neuronal localization of IL-1 type 1 receptors, including pre-synaptically and post-synaptically
Howard et al., Shock 2013 (Acute Lung Injury...) : Further analysis demonstrates prolonged preservation of aENaC expression by the activation of the heat shock response that involves inducible Hsp70. Inhibition of Hsp70 at 24 h after heat shock results in p38 dependent IL-1ß inhibition of aENaC mRNA expression, whereas overexpression of Hsp70 attenuates the p38 dependent IL-1ß inhibition of aENaC mRNA expression