◀ Back to TLR3
CXCL10 — TLR3
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CXCL10
→
TLR3
(increases, TLR3 Translocation, CXCL10 Activity)
Evidence: Poly(I:C), an analog of viral dsRNA and a TLR3 ligand,
Text-mined interactions from Literome
Rudd et al., J Virol 2005
:
Targeting the expression of
TLR3 with small interfering RNA decreased synthesis of IP-10/CXCL10 and CCL5 but did not significantly
reduce levels of
CXCL8
Park et al., Glia 2006
:
TLR3 mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes : differential signaling mechanisms of
TLR3 induced
IP-10 and IL-8 gene expression
Qian et al., Blood 2007
:
Blockade of IFN-alpha/beta
inhibits IP-10 production by
TLR agonist activated regulatory DCs
Maire et al., Biochem Biophys Res Commun 2008
:
Both
TLR3 and RIG-I are
required for
CXCL10 expression
Wang et al., Blood 2008
:
We and others have reported that
Toll-like receptor ( TLR ) proteins are present on human neutrophils and that granulocyte-macrophage colony stimulating factor ( GM-CSF ) treatment
enhances IL-8 (
CXCL8 ) secretion in response to stimulation with TLR ligands
Lee et al., Cell Microbiol 2009
:
In addition,
TLR2 , Dectin-1 and, to an extent, TLR4 are
essential for the MU-mediated expression of
CXCL8 , CCL2 and LL-37 in keratinocytes
Song et al., Viral Immunol 2011
:
Taken together, the results suggest that IL-8,
IP-10 , and GRO-a are predominantly induced in respiratory epithelial cells infected with influenza A viruses, and that TLR-5 and
TLR-3 are
involved in the stimulation of virus infected respiratory epithelial cells
Kwissa et al., Blood 2012
:
Furthermore, all
TLR-Ls induced rapid ( 3-8 hours ) expansion of CD14 ( + ) monocytes, but only TLR7/8-L and TLR9-L mobilized the CD14 ( + ) CD16 ( + ) and CD14 ( dim ) CD16 ( ++ ) monocytes, and only TLR7/8-L and TLR9-L
induced activation of myeloid dendritic cells ( mDCs ) and plasmacytoid DCs ( pDCs ), production of
IP-10 and type-I IFN, and expression of type-I IFN related and chemokine genes in the blood
Abe et al., J Virol 2012
:
In this study, we examined the
role of the
Toll-like receptor ( TLR ) pathway on
IP-10 production in cells replicating HCV
Ostvik et al., Inflamm Bowel Dis 2013
(Colitis, Ulcerative...) :
Enhanced expression of
CXCL10 in inflammatory bowel disease : potential
role of mucosal
Toll-like receptor 3 stimulation ... The TLR3-ligand poly ( I:C ) markedly increased release of CXCL10 in colonic epithelial cell lines, suggesting a
TLR3 mediated
CXCL10 release from mucosal epithelial cells in IBD patients
George et al., Biochem Biophys Res Commun 2012
(Hypertension, Pulmonary) :
Using specific TLR ligands, we found that activation of TLRs 3 and 4 resulted in IL-8 release by human pulmonary artery smooth muscle cells but that only
TLR3 stimulation
resulted in
IP10 and endothelin-1 release
Sharma et al., J Leukoc Biol 2013
:
Our findings reveal a previously unrecognized role for S1P in regulating
TLR induced
CXCL8 secretion from human T cells
Imaizumi et al., Am J Nephrol 2013
:
Using an RNA interfering technique,
involvement of
TLR3 , IFN-ß, melanoma differentiation associated gene 5 ( MDA5 ) or retinoic acid-inducible gene-I (RIG-I) in ISG56 expression, and of ISG56 in the expression of MDA5, RIG-I,
CXCL10 and CCL5 was examined