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PDGFB — SP1

Text-mined interactions from Literome

Rafty et al., Nucleic Acids Res 2001 : Sp1 phosphorylation regulates inducible expression of platelet derived growth factor B-chain gene via atypical protein kinase C-zeta
Rafty et al., J Cell Biochem 2002 : These findings thus demonstrate a pivotal role for Sp1 in pVHL inhibition of PDGF-B transcription
Wamhoff et al., Circ Res 2004 (Arteriosclerosis...) : To begin to assess mechanisms whereby the G/C repressor element mediates suppression of SM22alpha in atherosclerosis, we tested the hypothesis that effects may be mediated by platelet derived growth factor (PDGF)-BB induced increases in the G/C binding transcription factor Sp1 ... Consistent with this hypothesis, results of studies in cultured SMCs showed that : ( 1 ) PDGF-BB increased expression of Sp1 ; ( 2 ) PDGF-BB and Sp1 profoundly suppressed SM22alpha promoter activity as well as smooth muscle myosin heavy chain promoter activity through mechanisms that were at least partially dependent on the G/C cis element ; and ( 3 ) a short interfering RNA to Sp1 increased basal expression and attenuated PDGF-BB induced suppression of SM22alpha
Rafty et al., J Biol Chem 1998 : Conversely, overexpression of Sp1 in adult cells augments PDGF-B promoter dependent expression