Gene interactions and pathways from curated databases and text-mining

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HGF — SP1

Text-mined interactions from Literome

Friedrich et al., J Biol Chem 2002 : The crystal structure of the MT-SP1 complex with bovine pancreatic trypsin inhibitor serves as a model for hepatocyte growth factor activator inhibitor 1, the physiological inhibitor of MT-SP1 , and suggests determinants for the substrate specificity
Reisinger et al., J Cell Sci 2003 (Neovascularization, Pathologic) : Together, our results elucidate a critical pathway of paracrine amplification of angiogenesis, suggesting that HGF/SF induced Sp1 phosphorylation may activate VEGF/VPF promoter activity that requires the contribution of distinct signaling molecules
Tan et al., J Am Soc Nephrol 2007 (MAP Kinase Signaling System) : Chromatin immunoprecipitation assay revealed that activated CREB and Sp1 bound to their cognate cis acting elements in SnoN promoter in response to HGF stimulation