◀ Back to SP1
ETS1 — SP1
Pathways - manually collected, often from reviews:
-
BioCarta keratinocyte differentiation:
c/EBP-alpha (CEBPA)
→
SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
SP1
→
SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
SP1
→
ETS (ETS2/ETS1)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
HOXA7
→
SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA)
(modification, inhibits)
-
BioCarta keratinocyte differentiation:
SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA)
→
AP-1 complex (FOS-JUN)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA)
→
ETS (ETS2/ETS1)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
SP1
→
ETS (ETS2/ETS1)
(modification, collaborate)
-
FastForward regulation:
ETS1
→
SP1
(transcriptional regulation, unknown)
Hollenhorst et al., Genes Dev 2007
Evidence: DNABINDING, REG, PROMACTIVITY
-
FastForward regulation:
ETS1
→
SP1
(transcriptional regulation, increase)
Sato et al., J Biol Chem 2007*
Evidence: DNABINDING, REG, PROMACTIVITY
-
FastForward regulation:
SP1
→
ETS1
(transcriptional regulation, unknown)
Evidence: DNABINDING
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kavurma et al., J Biol Chem 2002
(Arteriosclerosis) :
Conversely,
Ets-1 activation of the promoter was
blocked by an
Sp1 mutant bearing the DNA binding domain
Liu et al., Eur J Biochem 2003
:
Gene transcription of fgl2 in endothelial cells is controlled by
Ets-1 and Oct-1 and
requires the presence of both
Sp1 and Sp3
Sato et al., J Biol Chem 2007
:
To solve this problem, we examined the transcriptional regulation of the human Sp1 gene by Ets-1 and found that the gene expression and promoter activity of
Sp1 are
regulated by
Ets-1 in cancer cells