Gene interactions and pathways from curated databases and text-mining

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CDK6 — SP1

Text-mined interactions from Literome

Lu et al., Mol Endocrinol 2000 (Adenocarcinoma...) : Androgen induction of cyclin dependent kinase inhibitor p21 gene : role of androgen receptor and transcription factor Sp1 complex
Cram et al., J Biol Chem 2001 (Breast Neoplasms) : Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter
PeƱuelas et al., Eur J Biochem 2003 : The expression of the transcription factor Sp1 , a retinoblastoma interacting protein, was also enhanced by all the cyclin dependent kinase inhibitors tested
Chew et al., J Biol Chem 2012 : Sulforaphane induction of p21 ( Cip1 ) cyclin dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53 dependent