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SMURF2 — TGFBR1

Pathways - manually collected, often from reviews:

• KEGG TGF-beta signaling pathway: SMURF1/SMURF2 → Complex of TGFBR1-TGFBR2 (protein-protein, inhibition)
• NCI Pathway Database TGF-beta receptor signaling: SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2) → TGFB/TGFBR2/TGFBR1/PML/SARA/SMAD2-3/AP2B2 complex (TGFBR1-PML-ZFYVE9-SMAD2_SMAD3-TGFBR2) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2) → TGFB/TGFBR2/TGFBR1 complex (TGFBR1-TGFBR2) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2) → TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: TGFB/TGFBR2/TGFBR1/PML/SARA/SMAD2-3/AP2B2 complex (TGFBR1-PML-ZFYVE9-SMAD2_SMAD3-TGFBR2) → TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: TGFB/TGFBR2/TGFBR1 complex (TGFBR1-TGFBR2) → TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: Caveolin-1 (CAV1) → TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2) → PML/SARA/SMAD2-3 complex (ZFYVE9-SMAD2_SMAD3-PML) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: SMURF2 (SMURF2) → TGFB/TGFBR2/TGFBR1/km23-1 complex (TGFBR1-TGFBR2-DYNLRB1) (modification, collaborate)
  Lin et al., J Biol Chem 2000, Bonni et al., Nat Cell Biol 2001, Tang et al., Mol Biol Cell 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TGF-beta receptor signaling: SMURF2 (SMURF2) → TGFB/TGFBR2/TGFBR1/km23-1/SMAD2 complex (TGFBR1-SMAD2-TGFBR2-DYNLRB1) (modification, collaborate)
  Lin et al., J Biol Chem 2000, Bonni et al., Nat Cell Biol 2001, Tang et al., Mol Biol Cell 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TGF-beta receptor signaling: TGFB/TGFBR2/TGFBR1/km23-1 complex (TGFBR1-TGFBR2-DYNLRB1) → SMAD2/SMURF2 complex (SMAD2-SMURF2) (modification, collaborate)
  Lin et al., J Biol Chem 2000, Bonni et al., Nat Cell Biol 2001, Tang et al., Mol Biol Cell 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TGF-beta receptor signaling: TGFB/TGFBR2/TGFBR1/km23-1/SMAD2 complex (TGFBR1-SMAD2-TGFBR2-DYNLRB1) → SMAD2/SMURF2 complex (SMAD2-SMURF2) (modification, collaborate)
  Lin et al., J Biol Chem 2000, Bonni et al., Nat Cell Biol 2001, Tang et al., Mol Biol Cell 2002
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: SMURF2 → TGFBR1 (indirect_complex) Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Kuratomi et al., Biochem J 2005
• Reactome Reaction: SMURF2 → TGFBR1 (reaction) Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Kuratomi et al., Biochem J 2005

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SMURF2 — TGFBR1 (physical association, affinity chromatography technology) Cai et al., J Dig Dis 2012*
• IRef Biogrid Interaction: SMURF2 — TGFBR1 (physical association, affinity chromatography technology) Kavsak et al., Mol Cell 2000
• IRef Biogrid Interaction: SMURF2 — TGFBR1 (physical association, affinity chromatography technology) Yan et al., Mol Cell Biol 2011
• IRef Corum Interaction: Complex of SMAD7-TGFBR1-TGFBR2-SMURF2 (association, anti tag coimmunoprecipitation) Kavsak et al., Mol Cell 2000
• IRef Hprd Interaction: SMURF2 — TGFBR1 (in vivo) Kavsak et al., Mol Cell 2000, Asano et al., J Clin Invest 2004*
• IRef Ophid Interaction: SMURF2 — TGFBR1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Asano et al., J Clin Invest 2004 (Scleroderma, Systemic) : There was no significant difference in Smurf1 and Smurf2 levels between normal and scleroderma fibroblasts, and the transiently overexpressed Smurf1 and/or Smurf2 did not affect TGF-beta receptor type I protein levels in scleroderma fibroblasts
Ohashi et al., FEBS Lett 2005 : TGF-beta mediated Smurf2 promoter activation was inhibited by Smad7 or an activin receptor-like kinase 5 inhibitor but not by dominant negative Smad or disruption of Smad binding elements in the promoter
Yang et al., J Histochem Cytochem 2009 : Overexpression of Smurf2 in HTR-8/SVneo cells reduced TGF-beta type I receptor levels, and enhanced cell migration and invasion ... Conversely, RNA interference mediated downregulation of Smurf2 resulted in a significant increase in TGF-beta type I receptor protein levels