Gene interactions and pathways from curated databases and text-mining

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CREBBP — SMAD3

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Hayashida et al., FASEB J 2003 (MAP Kinase Signaling System) : These results indicate that ERK dependent R-Smad linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells
Dennler et al., Oncogene 2005 : Such hypothesis was validated, as expression of a mutant form of SRC-1 lacking the CBP/p300 binding site failed to upregulate Smad3/4 dependent transcription, while full-length SRC-1 potentiated p300.Smad3 interactions
Ryoo et al., Gene 2006 : The establishment of an in vitro model system has enabled the investigation of intracellular events including BMP receptor activation, BMP-2 induced R-Smad activation , and kinase activation, and the role of osteogenic transcription factors, such as Runx2, Osx, Dlx5, and Msx2
Inoue et al., Oncogene 2007 : Moreover, p300/CBP potentiated the transcriptional activity of GAL4-Smad3C, but not the acetylation-resistant GAL4-Smad3C ( K378R ) mutant
Wang et al., Am J Physiol Heart Circ Physiol 2007 : In I-Smad7 infected cells, we also observed the ablation of TGF-beta(1) induced R-Smad2 phosphorylation vs. LacZ controls
Zode et al., Glia 2009 (Glaucoma) : Gremlin stimulation of ECM required activation of TGF-beta receptor and R-Smad3
Elshaier et al., Arthritis Rheum 2009 (MAP Kinase Signaling System) : IL-1beta reduced the number of activin receptor-like kinase 2 (ALK-2) and ALK-3 receptors, inhibited expression of Smad1 and Smad6, delayed and prematurely terminated the onset of OP-1 mediated R-Smad phosphorylation, and affected nuclear translocation of R-Smad/Smad4 complexes
Murakami et al., Genes Cells 2009 : Except for ALK4 and ALK6, levels of type I and type II receptor mRNAs were higher in B16 cells than in HeLa and HepG2 cells, in which TGF-beta1 and BMP-2 induced phosphorylation of only the expected R-Smad ... Except for ALK4 and ALK6, levels of type I and type II receptor mRNAs were higher in B16 cells than in HeLa and HepG2 cells, in which TGF-beta1 and BMP-2 induced phosphorylation of only the expected R-Smad
Fu et al., J Biol Chem 2009 : This is the first evidence that Notch activation affects R-Smad expression and that cooperative induction of histone acetylation at specific promoters underlies the selective synergy between Notch and TGFbeta signaling pathways
Yan et al., J Biol Chem 2009 : Here, we provide evidence that human BAMBI ( hBAMBI ), like its Xenopus homolog, inhibits TGF-beta- and BMP mediated transcriptional responses as well as TGF-beta induced R-Smad phosphorylation and cell growth arrest, whereas knockdown of endogenous BAMBI enhances the TGF-beta induced reporter expression
Cao et al., J Biol Chem 2010 : Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype
Park et al., PLoS Genet 2012 : We propose a model whereby DAF-8/R-Smad and NHR-69 negatively regulate the transcription of exp-2 to promote neuronal DAF-28 secretion, thus demonstrating a physiological crosstalk between TGF-ß and HNF4a-like signaling in C. elegans
Cheng et al., Chem Biol 2012 (MAP Kinase Signaling System) : We found that indirubin derivative E738 inhibited both TGFß and BMP pathways through ubiquitin-proteasome mediated depletion of total R-Smad pools, although phospho-R-Smad levels were initially stabilized by GSK3ß and cyclin dependent kinase inhibition
Wang et al., J Immunol 2013 (Nephritis, Interstitial) : Taken together, these data support a novel and direct role for NLRP3 in promoting TGF-ß signaling and R-Smad activation in epithelial cells independent of the inflammasome
Layliev et al., Gene Ther 2013 : R-SMAD nuclear translocation increased Dlx5 and Pai1 transcription ... R-SMAD nuclear translocation increased Dlx5 and Pai1 transcription
Shen et al., Mol Biol Cell 1998 : TGF-beta induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB binding protein