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P2RY12 — SELP
Text-mined interactions from Literome
Evans et al., Circulation 2009
(Atherosclerosis...) :
The
P2Y(12) receptor ( P2Y(12) )
plays a central role in amplifying platelet aggregation, dense granule and alpha-granule secretion,
P-selectin expression, microparticle formation, and procoagulant membrane changes, regardless of the activating stimulus
Judge et al., Thromb Haemost 2010
(Coronary Thrombosis) :
A
P2Y12 receptor blockade of 60-80 %
resulted in strong inhibition of final PA response,
P-selectin expression, microparticle formation and vasodilator stimulated phosphoprotein ( VASP )
Li et al., Arterioscler Thromb Vasc Biol 2012
(Atherosclerosis) :
In vitro studies showed that platelet
P2Y12 deficiency
suppressed platelet factor 4 secretion and
P-selectin expression