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ARHGEF11 — RHOA

Pathways - manually collected, often from reviews:

• KEGG Vascular smooth muscle contraction: ARHGEF1/ARHGEF11/ARHGEF12 → RHOA (protein-protein, activation)
• NCI Pathway Database Regulation of RhoA activity: PDZRhoGEF (ARHGEF11) → RHOA/GTP complex (RHOA) (modification, activates) Fukuhara et al., J Biol Chem 1999*, Oleksy et al., Acta Crystallogr D Biol Crystallogr 2004*, Oleksy et al., J Biol Chem 2006*, Gasmi-Seabrook et al., J Biol Chem 2010*
  Evidence: assay, physical interaction
• NCI Pathway Database Regulation of RhoA activity: PDZRhoGEF (ARHGEF11) → RHOA/GDP complex (RHOA) (modification, activates) Fukuhara et al., J Biol Chem 1999*, Oleksy et al., Acta Crystallogr D Biol Crystallogr 2004*, Oleksy et al., J Biol Chem 2006*, Gasmi-Seabrook et al., J Biol Chem 2010*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by focal adhesion kinase: PDZRhoGEF (ARHGEF11) → RHOA/GDP complex (RHOA) (modification, activates) Chikumi et al., J Biol Chem 2002*, Oleksy et al., Acta Crystallogr D Biol Crystallogr 2004*, Iwanicki et al., J Cell Sci 2008*, Gasmi-Seabrook et al., J Biol Chem 2010*
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: RHOA → ARHGEF11 (reaction) Reid et al., J Biol Chem 1999, Schmidt et al., Genes Dev 2002, Hirotani et al., Biochem Biophys Res Commun 2002, Oinuma et al., J Biol Chem 2003, Swiercz et al., J Cell Biol 2004, Jaffe et al., Annu Rev Cell Dev Biol 2005, Ramos-Morales et al., Oncogene 1995, Pasteris et al., Cell 1994, Hart et al., J Biol Chem 1994, Hart et al., J Biol Chem 1996, Zheng et al., J Biol Chem 1996, Van Aelst et al., Genes Dev 1997, Ren et al., J Biol Chem 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: ARHGEF11 — RHOA Derewenda et al., Structure 2004*
• IRef Bind_translation Interaction: ARHGEF11 — RHOA (x-ray crystallography) Derewenda et al., Structure 2004*
• IRef Biogrid Interaction: RHOA — ARHGEF11 (direct interaction, pull down) Rümenapp et al., FEBS Lett 1999*
• IRef Biogrid Interaction: RHOA — ARHGEF11 (direct interaction, enzymatic study) Rümenapp et al., FEBS Lett 1999*
• IRef Biogrid Interaction: RHOA — ARHGEF11 (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Dip Interaction: ARHGEF11 — RHOA (direct interaction, gdp/gtp exchange assay) Derewenda et al., Structure 2004*
• IRef Dip Interaction: ARHGEF11 — RHOA (direct interaction, x-ray crystallography) Derewenda et al., Structure 2004*
• IRef Dip Interaction: ARHGEF11 — RHOA (direct interaction, molecular sieving) Derewenda et al., Structure 2004*
• IRef Hprd Interaction: ARHGEF11 — RHOA (in vitro) Rümenapp et al., FEBS Lett 1999*, Derewenda et al., Structure 2004*
• IRef Intact Interaction: ARHGEF11 — RHOA (direct interaction, x-ray crystallography) Derewenda et al., Structure 2004*
• IRef Intact Interaction: ARHGEF11 — RHOA (physical association, anti tag coimmunoprecipitation) Dong et al., EMBO J 2010*
• IRef Intact Interaction: ARHGEF11 — RHOA (physical association, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Ophid Interaction: ARHGEF11 — RHOA (aggregation, confirmational text mining) Rümenapp et al., FEBS Lett 1999*
• IRef Ophid Interaction: ARHGEF11 — RHOA (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Swiercz et al., J Cell Biol 2004 : Plexin-B1 has recently been shown to mediate activation of RhoA through a stable interaction with the Rho guanine nucleotide exchange factors PDZ-RhoGEF and LARG
Ying et al., Arterioscler Thromb Vasc Biol 2009 (Calcium Signaling) : Results showed that overexpression of PDZ-RhoGEF , but not p115-RhoGEF or leukemia associated RhoGEF (LARG), enhanced RhoA activation by angiotensin II ... PYK2 and PDZ-RhoGEF are necessary for angiotensin II-induced RhoA activation and for Ca ( 2+ ) signaling to RhoA
Gasmi-Seabrook et al., J Biol Chem 2010 : Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF
Okuhira et al., J Biol Chem 2010 : Binding of PDZ-RhoGEF to ATP binding cassette transporter A1 ( ABCA1 ) induces cholesterol efflux through RhoA activation and prevention of transporter degradation ... Exogenous PDZ-RhoGEF expression activated RhoA and increased ABCA1 protein levels and cholesterol efflux activity