Zhang et al., J Biol Chem 1999
:
In vitro studies demonstrated that TNF-alpha induced endothelial cell syndecan-4 expression by both increasing syndecan-4 gene expression in an NF-kappaB dependent manner and by prolonging syndecan-4 mRNA half-life
Smith et al., Glycobiology 2006
:
Helicobacter pylori and toll-like receptor agonists induce syndecan-4 expression in an NF-kappaB dependent manner ... The H. pylori- and TLR induced increase in syndecan-4 mRNA was blocked by the proteosome inhibitor MG-132 suggesting a role for nuclear factor kappaB (NF-kappaB) in the regulation of syndecan-4 gene expression ... These results thus demonstrate that the response of the syndecan-4 gene to infectious agents, or their products, is a direct result of NF-kappaB binding to the promoter and induction of de novo transcription