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KLF2 — RELA
Text-mined interactions from Literome
Lin et al., Arterioscler Thromb Vasc Biol 2006
:
Mechanistically,
KLF2 inhibits PAR-1 expression and, as a consequence, thrombin
mediated nuclear factor kappaB (NF-kappaB) nuclear accumulation and DNA binding ... Conversely, small interfering RNA mediated knockdown of
KLF2 increases PAR-1 expression and thrombin mediated
induction of
NF-kappaB activation
Das et al., Proc Natl Acad Sci U S A 2006
(Atherosclerosis...) :
Mechanistically,
KLF2 inhibits the transcriptional activity of both
NF-kappaB and activator protein 1, in part by means of recruitment of transcriptional coactivator p300/CBP associated factor
Zahlten et al., J Immunol 2010
(Disease Models, Animal...) :
KLF2 dependent downregulation of
NF-kappaB activity is partly reversible by overexpression of the histone acetylase p300/CREB binding protein associated factor