Qiao et al., J Immunol 2007
:
Together, our data suggest that Cbl-b attenuates CD40 mediated NF-kappaB and JNK activation, thereby suppressing B cell responses
Veber et al., J Neurosci Res 2008
(Vitamin B 12 Deficiency) :
We used electrophoretic mobility shift assays to investigate the effects of cobalamin (Cbl) deficiency on the levels of activated nuclear factor-kappa B (NF-kappaB) in the spinal cords ( SCs ) and livers of rats made Cbl-deficient (Cbl-D) by total gastrectomy or a Cbl-D diet
Qiao et al., Mol Cell Biol 2008
:
T-cell receptor induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b ... In this study, we report that the loss of Cbl-b selectively results in aberrant activation of NF-kappaB upon T-cell antigen receptor ( TCR ) ligation, which is mediated by phosphatidylinositol 3-kinase (PI3-K)/Akt and protein kinase C-theta (PKC-theta)