Gene interactions and pathways from curated databases and text-mining

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PXN — TNF

Text-mined interactions from Literome

Boecke et al., Br J Cancer 2013 (Melanoma, Experimental...) : Furthermore, FAN mediated TNF induced paxillin phosphorylation, metalloproteinase activation and increased extracellular matrix degradation, the hallmarks of functionally active invadopodia.Conclusion : The results of our study suggest that FAN through promoting melanoma cellular motility and tumour invasiveness is critical for the tumour promoting action of TNF
Fuortes et al., J Cell Biol 1994 : In the present work, tumor necrosis factor-alpha (TNF) stimulated tyrosine phosphorylation of paxillin in human neutrophils