Gene interactions and pathways from curated databases and text-mining

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MSH4 — PPARA

Text-mined interactions from Literome

Maresca et al., Pigment Cell Melanoma Res 2013 (Melanoma, Experimental...) : As the melanocortin-1 receptor, the specific receptor for the a-MSH, is a G-protein coupled receptor, we wondered whether the phosphatidylinositol [ PI ( 4,5 ) P ( 2 ) /PLC ( ß ) ] signal pathway was involved in mediating the a-MSH dependent PPAR-? activation ... Employing inhibitors of PI ( 4,5 ) P ( 2 ) /PLC ( ß ) pathway, the results of our experiments suggested that this pathway was promoted by a-MSH and that a-MSH played a role in mediating PPAR-? activation ... The a-MSH effect on PPAR-? was independent of animal species and was not correlated with the physio-pathological status
Carniglia et al., PloS one 2013 : Effect of NDP-a-MSH on PPAR-? and -ß Expression and Anti-Inflammatory Cytokine Release in Rat Astrocytes and Microglia