Egerod et al., Toxicol Pathol 2009
:
PPAR alpha and PPAR gamma coactivation rapidly induces Egr-1 in the nuclei of the dorsal and ventral urinary bladder and kidney pelvis urothelium of rats ... Finally, our demonstration of a nuclear localization supports that the Egr-1 induced by PPAR alpha and PPAR gamma coactivation in the rat urothelium may be biologically active
Nebbaki et al., Arthritis Res Ther 2012
(Osteoarthritis) :
In this study, our objective was to define the roles of Egr-1 and Sp1 in IL-1 mediated down-regulation of PPAR? expression ... Overexpression of Egr-1 potentiated , whereas overexpression of Sp1 alleviated, the suppressive effect of IL-1 on the PPAR? promoter, suggesting that Egr-1 may mediate the suppressive effect of IL-1
Wan et al., Translational research : the journal of laboratory and clinical medicine 2012
(Acute Disease...) :
The purpose of this study was to test the hypothesis that activation of endogenous peroxisome proliferator activated receptor ( PPAR? ) inhibits induction of early growth response factor-1 (Egr-1) , which is rapidly induced in the pancreas following cerulein intraperitoneal injection ... Activation of PPAR-? suppressed the activation of Egr-1 and its inflammatory gene targets and provided potent protection against pancreas injury