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MDM2 — PML

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: MDM2 — PML Bernardi et al., Nat Cell Biol 2004*
• IRef Bind_translation Interaction: MDM2 — PML (affinity chromatography technology) Bernardi et al., Nat Cell Biol 2004*
• IRef Bind_translation Interaction: MDM2 — PML (coimmunoprecipitation) Bernardi et al., Nat Cell Biol 2004*
• IRef Bind_translation Interaction: MDM2 — PML (unspecified method) Bernardi et al., Nat Cell Biol 2004*
• IRef Biogrid Interaction: MDM2 — PML (physical association, affinity chromatography technology) Zhu et al., J Biol Chem 2003*
• IRef Biogrid Interaction: MDM2 — PML (direct interaction, pull down) Zhu et al., J Biol Chem 2003*
• IRef Biogrid Interaction: MDM2 — PML (physical association, affinity chromatography technology) Wei et al., J Biol Chem 2003*
• IRef Biogrid Interaction: MDM2 — PML (direct interaction, pull down) Wei et al., J Biol Chem 2003*
• IRef Biogrid Interaction: MDM2 — PML (physical association, affinity chromatography technology) Kurki et al., J Cell Sci 2003*
• IRef Biogrid Interaction: MDM2 — PML (direct interaction, pull down) Kurki et al., J Cell Sci 2003*
• IRef Biogrid Interaction: MDM2 — PML (direct interaction, enzymatic study) Chu et al., Oncogene 2011*
• IRef Biogrid Interaction: MDM2 — PML (physical association, affinity chromatography technology) Wu et al., J Biol Chem 2009*
• IRef Biogrid Interaction: MDM2 — PML (direct interaction, pull down) Bernardi et al., Nat Cell Biol 2004*
• IRef Biogrid Interaction: MDM2 — PML (physical association, affinity chromatography technology) Bernardi et al., Nat Cell Biol 2004*
• IRef Hprd Interaction: PML — MDM2 (in vivo) Wei et al., J Biol Chem 2003*, Kurki et al., J Cell Sci 2003*, Zhu et al., J Biol Chem 2003*, Bernardi et al., Nat Cell Biol 2004*
• IRef Hprd Interaction: PML — MDM2 (in vitro) Wei et al., J Biol Chem 2003*, Kurki et al., J Cell Sci 2003*, Zhu et al., J Biol Chem 2003*, Bernardi et al., Nat Cell Biol 2004*
• IRef Intact Interaction: Complex of PML-MDM2-TP53-PML-MDM2-TP53 (direct interaction, anti bait coimmunoprecipitation) Kurki et al., J Cell Sci 2003*
• IRef Intact Interaction: MDM2 — PML (colocalization, imaging technique) Kurki et al., J Cell Sci 2003*
• IRef Intact Interaction: MDM2 — PML (physical association, anti bait coimmunoprecipitation) Kurki et al., J Cell Sci 2003*
• IRef Intact Interaction: MDM2 — PML (direct interaction, coimmunoprecipitation) Kurki et al., J Cell Sci 2003*
• IRef Intact Interaction: MDM2 — PML (direct interaction, imaging technique) Kurki et al., J Cell Sci 2003*
• IRef Ophid Interaction: MDM2 — PML (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Bernardi et al., Nat Cell Biol 2004 : PML was recently shown to interact with the p53 ubiquitin-ligase Mdm2 ( refs 4-6 ) ; however, the mechanism by which PML regulates Mdm2 remains unclear
Yang et al., Oncogene 2013 : Doxorubicin, a common chemotherapeutic agent, is known to promote PML mediated p53 activation in part by promoting PML dependent MDM2 nucleolar sequestration