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CIB1 — PCNA

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Hsu et al., Exp Cell Res 2000 (Carcinoma, Squamous Cell...) : Evaluation of the kinase activity of cyclin-Cdk complexes showed that RA increases p27 ( Kip1 ) expression in CH27 cells leading to markedly reduced cyclin A/Cdk2 kinase activity and slightly reduced cyclin E/Cdk2 kinase activity, with no effect on cyclin D/Cdk4 and cyclin D/Cdk6 activities
Klausen et al., Oncogene 2000 : These processes were accompanied by a decrease in cyclin A expression and CDK2 activity, and enhanced accumulation of p27kip1
Favot et al., Thromb Haemost 2004 : The role of PDE2 and PDE4 in VEGF induced proliferation in HUVEC was investigated : 1 ) VEGF increased cAMP-hydrolytic activity by up-regulating the expression of PDE2 and PDE4 isozymes ; 2 ) VEGF increased progression in cell cycle with an increase in p42/p44 MAP kinase, cyclin A and cyclin D1 expressions and with a decrease in p21 waf1/cip1 and p27 kip1 expressions ; 3 ) EHNA ( 20 micro M ), a selective PDE2 inhibitor, RP73401 ( 10 micro M ), a selective PDE4 inhibitor blocked the VEGF induced increase in p42/p44 MAP kinase expression ; 4 ) RP73401, but not EHNA, blocked the VEGF induced increase in cyclin A and decrease in p27 kip1 expressions ; 5 ) EHNA, contrary to RP73401, enhanced the VEGF induced increase of cyclin A and decrease of p27 kip1
Yu et al., J Pharmacol Sci 2008 : Western blot analysis showed that genistein not only inhibited phosphorylation of retinoblastoma protein ( pRb ) and expression of cyclin E, cyclin dependent kinase (CDK) 2, and proliferating cell nuclear antigen ( PCNA ) protein, but also inhibited downregulation of cyclin dependent kinase inhibitor (CKI) p27kip1
Schulze et al., Mol Cell Biol 1996 : These data suggest that the block to cyclin A transcription in nonadherent NIH 3T3 cells results from stabilization of p27KIP1 and subsequent inactivation of the specific E2F moiety required for its induction
Dong et al., Mol Biol Cell 1998 : Cyclin D3-associated kinase activity is regulated by p27kip1 in BALB/c 3T3 cells
Muro-Cacho et al., Arch Otolaryngol Head Neck Surg 1999 (Carcinoma, Papillary...) : In a retrospective study, the expression of transforming growth factor beta receptors types I and II, cyclin D1, and the cyclin dependent inhibitor p27kip , was analyzed by immunohistochemistry