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APP — NTRK1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes receptor complex:
receptor complex complex (PTH1R-TAOK2-VLDLR-TGFBR2-GABRG1-KCTD8-EGFR-RET-NTRK1-RIPK1-INSR-TRPC1-INSRR-GABRA5-FLT4-ADCYAP1R1-GPR37-P2RX2-LOXL4-IMPG2-PKD1L3-NOTCH1-ADRA2A-TRADD-LRP2-MTTP-GPR101-ITLN1-VIPR1-CD200R1-GRM7-GPR84-FCRL5-RNMT-ITGB1-NPR1-SLITRK5-IL4R-KCTD12-PLA2R1-RAMP1-RXRA-RAMP2-PIGR-GPR62-GPR63-GPR61-ITPR3-GPR20-MTNR1A-ROR1-ABCG5-CR2-GPR37L1-LRP1-LRP6-KCTD16-LRP5-CR1L-NTRK2-APP-GABRQ-CSF1-ABCG8-ADRB2-ADRB3-TLR7-GPR119-TAS1R2)
Roka et al., Mol Pharmacol 1999, Small et al., J Biol Chem 2000, Graf et al., J Biol Chem 2003, Breit et al., J Biol Chem 2004, Bomberger et al., J Biol Chem 2005, Turunen et al., Nucleic Acids Res 2007, Ding et al., J Cell Biol 2008, Ghai et al., Proc Natl Acad Sci U S A 2013, Lin et al., J Biol Chem 1995, Hsu et al., Immunity 1996, Zhang et al., Nature 1996
Text-mined interactions from Literome
Rossner et al., Neurosci Lett 1999
:
We have shown recently in the pheochromocytoma PC-12 cell line, that the activation of the high-affinity receptor for nerve growth factor (NGF),
tyrosine kinase receptor (TrkA) ,
results in increased secretion of the
amyloid precursor protein (APP) into the culture medium
Tarr et al., Biochem Biophys Res Commun 2002
:
Here we present evidence that the nerve growth factor receptor
TrkA may also
promote phosphorylation of
APP ... Overexpression of
TrkA , but not of mutated, kinase inactive TrkA
resulted in tyrosine phosphorylation of
APP
Wallace et al., Brain Res Mol Brain Res 1997
:
The neurotrophic activity of
APP was
independent of the
TrkA NGF receptor because neither phospholipase C-gamma1 nor TrkA exhibited tyrosine phosphorylations with APP treatment
Rossner et al., J Neurochem 1998
:
The pheochromocytoma PC12 cell line was used as a model system to characterize the
role of the p75 neurotrophin receptor (p75NTR) and
tyrosine kinase (Trk) A nerve growth factor (NGF) receptors on
amyloid precursor protein (APP) expression and processing ... Specific stimulation of
TrkA receptors by receptor cross linking, on the other hand, selectively
stimulated neurite outgrowth and APP secretion but not
APP mRNA levels, which were decreased