Gene interactions and pathways from curated databases and text-mining

◀ Back to MCM2

MCM2 — MCM5

Pathways - manually collected, often from reviews:

  • BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Mcm2-7/SCF complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-KITLG) → ORC/CDC6/CDT1/Mcm2-7 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7) (modification, collaborate)
  • BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Mcm2-7/SCF complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-KITLG) → KITL (KITLG) (modification, collaborate)
  • BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Mcm2-7 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7) → KITL (KITLG) (modification, collaborate)
  • BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Mcm2-7 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7) → Mcm2-7 complex (MCM2-MCM3-MCM4-MCM5-MCM6-MCM7) (modification, collaborate)
  • BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Mcm2-7 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7) → ORC/CDC6/CDT1 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1) (modification, collaborate)
  • BioCarta cdk regulation of dna replication: Mcm2-7 complex (MCM2-MCM3-MCM4-MCM5-MCM6-MCM7) → ORC/CDC6/CDT1 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1) (modification, collaborate)
  • BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Mcm2-7/SCF complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-KITLG) → ORC/CDC6/CDT1/Cyclin E/CDK2/p27 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-CCNE1-CDK2-CDKN1B) (regulation of DNA replication initiation, activates)
  • KEGG Cell cycle: Complex of ORC1-ORC2-ORC3-ORC4-ORC5-ORC6 → Complex of MCM2-MCM3-MCM4-MCM5-MCM6-MCM7 (protein-protein, binding/association)
  • KEGG Cell cycle: CDC45 → Complex of MCM2-MCM3-MCM4-MCM5-MCM6-MCM7 (protein-protein, binding/association)
  • KEGG Cell cycle: Complex of CDC7-DBF4 → Complex of MCM2-MCM3-MCM4-MCM5-MCM6-MCM7 (protein-protein, phosphorylation)
  • Reactome Reaction: MCM2 → MCM5 (reaction) Sato et al., J Mol Biol 2000, Schaarschmidt et al., Nucleic Acids Res 2002
  • Reactome Reaction: MCM2 → MCM5 (direct_complex)
  • WikiPathways Cell Cycle: CDC7/DBF4 → Complex of MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-MCM8-MCM9-MCM10 (activation)
  • WikiPathways Cell Cycle: CDC45 → Complex of MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-MCM8-MCM9-MCM10 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Findeisen et al., Eur J Biochem 1999 : High cyclin E kinase activity allows the binding of Xenopus ORC and Cdc6, but not MCM , to sperm chromatin, even though the kinase does not phosphorylate MCM directly
Odom et al., Science 2000 : The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was found to be identical to Arg82 , a regulator of the transcriptional complex ArgR-Mcm1
Izumi et al., Nucleic Acids Res 2000 : Mcm10 is a nuclear protein that is localized to replication origins and mediates the interaction of the Mcm2-7 complex with replication origins
Murphy et al., Vet Surg 2000 : These effects were prevented in the canine explants by simultaneous treatment with MPS at 1 and 0.1 mg/mL, and proteoglycan release induced by MCM in equine articular cartilage was inhibited by 1 mg/mL MPS
Measday et al., Genes Dev 2002 : We used chromatin immunoprecipitation to demonstrate that Ctf3p, Mcm22p, and Mcm16p bind to CEN DNA in a Ctf19p dependent manner
Wohlschlegel et al., Mol Cell 2002 : Current models suggest that the replication initiation factor Mcm10 is required for association of Mcm2-7 with origins of replication to generate the prereplicative complex (pre-RC)
You et al., J Biol Chem 2002 : Because uncomplexed Mcm7 displayed neither ATPase nor DNA helicase activity, Mcm7 contributes to the DNA helicase activity of the Mcm complex through interaction with other subunits
Tesfaigzi et al., J Immunol 2002 (Eosinophilia...) : IFN-gamma caused Bax expression in IL-13 induced MCM in microdissected airway cultures
Fennessy et al., Circulation 2003 : MCM taken from smokers impaired the release of nitric oxide and increased the levels of endothelin-1 release from HUVECs
Gregan et al., Mol Biol Cell 2003 : However, unlike the situation in Xenopus, where Mcm10 chromatin binding is dependent on Mcm2-7 , we show that the fission yeast protein is bound to chromatin throughout the cell cycle in growing cells, and only displaced from chromatin during quiescence
Bruemmer et al., Exp Cell Res 2003 (Coronary Restenosis...) : In combination, these data demonstrate that the ERK/MAPK signal transduction pathway plays a central role in regulating E2F dependent MCM expression and DNA replication in VSMC
Savli et al., Int J Neurosci 2004 : In the present study, the authors aimed to evaluate the effect of microglia conditioned medium (MCM) on brain derived neurotrophic factor (BDNF) gene expression of astrocytes by quantitative real-time polymerase chain reaction ( PCR )
Peterson et al., Biochem Pharmacol 1992 (Liver Diseases) : Catalase partially blocked the AHH inhibitory activity of MCM suggesting that activated oxygen intermediates are partially involved in the AHH inhibitory activity of the MCM
Venugopal et al., Am J Pathol 2005 : To mimic the in vivo situation, we examined whether vascular smooth muscle cell ( VSMC ) and/or macrophage conditioned media (MCM) could augment CRP production by HAEC
Juang et al., Chemosphere 2006 : It was experimentally concluded that when the effect of interactions between large dyes ( such as BV10 ) and MCM-41 on the pore structure stability of MCM-41 was insignificant, MCM-41 might be a good adsorbent for the removal of basic dyes from wastewater
Kasiviswanathan et al., J Bacteriol 2006 : Using minichromosome maintenance (MCM) helicase mutant proteins unable to bind DNA, it was found that the interaction of MCM with Cdc6 inhibits the DNA binding activity of Cdc6
Kawasaki et al., Genes Cells 2006 : However, Mcm2-7p does bind in the presence of exogenous Cdt1p or Cdt1p-Mcm2-7p complex
Peng et al., Glia 2006 (AIDS Dementia Complex...) : The MCM induced production of SDF-1 was prevented by IL-1beta receptor antagonist (IL-1Ra) and IL-1beta siRNA treatment of human MDM. These laboratory observations were confirmed in severe combined immunodeficient ( SCID ) mice with HIV-1 encephalitis ( HIVE )
Xiang et al., Am J Respir Cell Mol Biol 2008 (Metaplasia) : IL-9 or IL-13 induced MCM independently, but a combined IL-9/IL-13 treatment enhanced MCM synergistically ... IL-9 or IL-13 induced MCM independently, but a combined IL-9/IL-13 treatment enhanced MCM synergistically ... While IL-9/IL-13 induced MCM in bronchioles microdissected from bax ( +/+ ) and bax ( -/- ) mice to a similar extent, IFN-gamma treatment reduced MCM only in bronchioles from bax ( +/+ ) but not in bax ( -/- ) bronchioles ... While IL-9/IL-13 induced MCM in bronchioles microdissected from bax ( +/+ ) and bax ( -/- ) mice to a similar extent, IFN-gamma treatment reduced MCM only in bronchioles from bax ( +/+ ) but not in bax ( -/- ) bronchioles
Peng et al., Glia 2008 (HIV Infections) : Conditioned media from lipopolysaccharide (LPS) activated MDM ( LPS-MCM ) or HIV infected MCM ( HIV-MCM ) induced a profound increase in NPC proliferation
Xie et al., Proc Natl Acad Sci U S A 2008 : We show by alpha-amanitin inhibition that RNA polymerase II (RNAPII) transcription is required to localize MCM2-7 ( but not ORC ) to permit the second round of origin firing
Pawluczyk et al., Nephrol Dial Transplant 2009 (Disease Models, Animal...) : Fibronectin and IL-1beta levels were enhanced proportionately between the sexes in response to MCM stimulation, whilst the increase in TNFalpha levels was greater in MCM stimulated female cells ... Fibronectin and IL-1beta levels were enhanced proportionately between the sexes in response to MCM stimulation, whilst the increase in TNFalpha levels was greater in MCM stimulated female cells
Hu et al., Glia 2009 : Bath application of LPS stimulated MDM conditioned media (MCM) enhanced neuronal I ( K ) in a concentration dependent manner, whereas non stimulated MCM failed to alter neuronal I ( K )
Majid et al., Cancer Res 2010 (Prostatic Neoplasms) : Here, we examined the role of MCM2 in prostate cancer and the effect of microRNA-1296 (miR-1296), genistein, and trichostatin A (TSA) on the MCM complex ... Here, we examined the role of MCM2 in prostate cancer and the effect of microRNA-1296 (miR-1296) , genistein, and trichostatin A (TSA) on the MCM complex ... Here, we examined the role of MCM2 in prostate cancer and the effect of microRNA-1296 (miR-1296), genistein, and trichostatin A (TSA) on the MCM complex
Kundu et al., Nucleic Acids Res 2010 : Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7 mediated phosphorylation of Mcm2-7 complex ... Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7 mediated phosphorylation of Mcm2-7 complex ... Remarkably, Cdc6 itself does not directly inhibit Cdc7 kinase activity towards Mcm2-4-6-7 in purified systems, rather modulates Mcm2-7 phosphorylation on chromatin context ... Remarkably, Cdc6 itself does not directly inhibit Cdc7 kinase activity towards Mcm2-4-6-7 in purified systems, rather modulates Mcm2-7 phosphorylation on chromatin context ... Taken together, we propose that Cdc6 on chromatin acts as a modulator of Cdc7 mediated phosphorylation of Mcm2-7 , and thus destabilization of Cdc6 from chromatin after licensing is a key event ensuring proper transition to the initiation of DNA replication
Han et al., Genes Dev 2010 : Loss of Rtt101 also reduces binding of FACT to MCM , but not the association of FACT with Leo1 and Spt5, two proteins involved in transcription
Mogavero et al., Antimicrob Agents Chemother 2011 : These results demonstrate a differential requirement for the coregulator Mcm1 for Cap1- and Mrr1 mediated MDR1 upregulation ... These results demonstrate a differential requirement for the coregulator Mcm1 for Cap1- and Mrr1 mediated MDR1 upregulation
Stead et al., Nucleic Acids Res 2011 : In vitro, phosphorylation of Mcm2 or Mcm2 ( EE ) reduces the helicase activity of Mcm2-7 while increasing DNA binding ... In vitro, phosphorylation of Mcm2 or Mcm2 ( EE ) reduces the helicase activity of Mcm2-7 while increasing DNA binding
Chen et al., J Biol Chem 2011 (MAP Kinase Signaling System) : By using specific inhibitors and small interfering RNAs, we demonstrate that the activation of the JNK and p38 MAPK pathways are critical for HG-MCM induced E-selectin expression ... The inhibition of NF-?B and AP-1 activation by specific siRNAs blocks the HG-MCM induced E-selectin promoter activity and expression
Dang et al., J Biol Chem 2011 : Here, we demonstrated that the CMG complex is formed in vivo in trypanosomes and that Mcm2-7 helicase activity is activated by the association with Cdc45 and the GINS complex in vitro ... Here, we demonstrated that the CMG complex is formed in vivo in trypanosomes and that Mcm2-7 helicase activity is activated by the association with Cdc45 and the GINS complex in vitro
Bruck et al., J Biol Chem 2011 : Sld2 interaction with Mcm2-7 blocks the interaction between GINS and Mcm2-7
Wu et al., J Cell Sci 2012 : We demonstrate that disruption of the interaction between Cdt1p and Mcm6p prevents the formation of the MCM complex , excludes Mcm2-7p from the nucleus, and inhibits pre-RC assembly and DNA replication ... We demonstrate that disruption of the interaction between Cdt1p and Mcm6p prevents the formation of the MCM complex , excludes Mcm2-7p from the nucleus, and inhibits pre-RC assembly and DNA replication
Cho et al., Proc Natl Acad Sci U S A 2013 : The Tim-Tipin complex, reconstituted and purified using the baculovirus expression system, interacts directly with Mcm complexes and inhibits the single stranded DNA dependent ATPase activities of the Mcm2-7 and Mcm4/6/7 complexes, the DNA unwinding activity of the Mcm4/6/7 complex, and the DNA unwinding and ATPase activity of Cdc45-Mcm2-7-GINS complex, the presumed replicative DNA helicase in eukaryotes ... The effects of Tim-Tipin on the catalytic activities of the Mcm complexes and DNA pols are mediated by the Tim protein alone, and distinct regions of the Tim protein are responsible for the inhibition of Mcm complex activities and stimulation of DNA pols
Evrin et al., Nucleic Acids Res 2013 : Our findings illustrate how conserved Cdc6 AAA+ motifs modulate MCM2-7 recruitment, show that ATPase activity is required for MCM2-7 hexamer dimerization and demonstrate that MCM2-7 hexamers are recruited to origins in a consecutive process
Hubbi et al., Science signaling 2013 : In response to hypoxia, HIF-1a bound to Cdc6, a protein that is essential for loading of the minichromosome maintenance (MCM) complex ( which has DNA helicase activity ) onto DNA, and promoted the interaction between Cdc6 and the MCM complex ... Although the interaction between Cdc6 and the MCM complex increased the association of the MCM proteins with chromatin, the binding of HIF-1a to the complex decreased phosphorylation and activation of the MCM complex by the kinase Cdc7 ... Although the interaction between Cdc6 and the MCM complex increased the association of the MCM proteins with chromatin, the binding of HIF-1a to the complex decreased phosphorylation and activation of the MCM complex by the kinase Cdc7
Das et al., PloS one 2013 : Binding and function of MCM2-7 to pre-replication complex is regulated by MCM10 mediated binding of RECQL4 with MCM2-7
Stefanovic et al., Kidney Int 1989 : The effect of MCM on ecto-5'-nucleotidase activity was apparent after 24 hours and increased with time
Wang et al., Mol Gen Genet 1994 : It has been previously demonstrated that MCM1 and STE12 are transcriptional activators of a-specific genes such as STE6 , and we now show that SWI1 is also required for STE6 expression
Sible et al., Curr Biol 1998 : The periodic association of the MCM complex with chromatin may be regulated via phosphorylation by cyclin dependent kinases (Cdks) [ 11 ]
Behzadian et al., Glia 1998 (Anoxia) : Adsorption of MCM by specific antibodies as well as Western and Northern blot analysis indicated that stimulating and inhibitory activities of MCM are due to the presence of VEGF and TGF-beta, respectively
Culig et al., Br J Cancer 1998 (Prostatic Neoplasms) : The effects of MCM on cellular proliferation, AR protein and PSA secretion were abolished by pretreatment of MCM with a neutralizing anti-IL-1beta antibody