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EGFR — IL8
Text-mined interactions from Literome
Venkatakrishnan et al., J Biol Chem 2000
(Ovarian Neoplasms) :
Of note,
IL-8 induced transient phosphorylation of the
epidermal growth factor (EGF) receptor and its association with the adaptor molecules Shc and Grb2
Bancroft et al., Int J Cancer 2002
(Carcinoma, Squamous Cell...) :
We conclude that antagonists of EGFR, PI3K and MEK signal pathways have inhibitory activity against
EGFR induced NF-kappaB and AP-1 activation,
IL-8 and VEGF expression and growth by HNSCC
Hamilton et al., Clin Exp Allergy 2003
(Asthma...) :
Using H292 cells, EGF and H2O2 increased
IL-8 gene expression and release and this was completely
suppressed by the
EGFR-selective tyrosine kinase inhibitor, AG1478, but only partially by dexamethasone ... These results suggest that in severe asthma, epithelial damage has the potential to contribute to neutrophilic inflammation through enhanced production of
IL-8 via
EGFR- dependent mechanisms
Tanida et al., Gastroenterology 2004
(Stomach Neoplasms) :
KB-R7785 completely blocked
IL-8 induced shedding and
EGFR transactivation ... Depletion of ADAM10 also dramatically reduced
IL-8 induced shedding and
EGFR transactivation, but depletion of ADAM12 and 17 did not
Itoh et al., Cytokine 2005
(Carcinoma...) :
IL-8 transiently
induced EGFR tyrosine phosphorylation after 5-90 min and this was completely inhibited by ADAM inhibitor
Joh et al., Dig Dis Sci 2005
:
IL-8 also
induced EGFR phosphorylation, while anti-IL-8 and anti-IL-8 receptor ( CXCR1 ) neutralizing antibodies suppressed
EGFR phosphorylation
Chokki et al., Life Sci 2006
:
Since recent studies demonstrated that the stimulation of
epidermal growth factor receptor (EGFR) could
induce IL-8 secretion, the involvement of EGFR in TNF-alpha induced IL-8 secretion in airway epithelium-like NCI-H292 cells was investigated in this study ... Inhibition of the
EGFR by either an anti-EGFR neutralizing antibody or by its specific inhibitor AG1478 ( 1 microM )
blocked TNF-alpha induced
IL-8 secretion ... These findings indicate that metalloprotease mediated AR shedding and subsequent activation of
EGFR play a critical role in TNF-alpha induced
IL-8 secretion from the human airway epithelium-like NCI-H292 cells, and that TACE is one of the most possible candidates for metalloprotease responsible for TNF-alpha induced AR shedding
Zhao et al., J Biol Chem 2006
:
Furthermore, down-regulation of
EGFR by EGFR small interfering RNA or pretreatment of cells with EGFR inhibitors AG1478 and PD158780 almost completely blocked LPA dependent EGFR phosphorylation and partially
attenuated IL-8 secretion, respectively ... These results demonstrate that LPA induced
IL-8 secretion is partly
dependent on
EGFR transactivation regulated by PKCdelta dependent activation of Lyn kinase and MMPs and proHB-EGF shedding, suggesting a novel mechanism of cross-talk and interaction between G-protein coupled receptors and receptor-tyrosine kinases in HBEpCs
Liu et al., J Biol Chem 2008
(Asthma...) :
The
EGFR inhibitor AG1478, completely
blocked IL-8 and ICAM-1 expression to basal levels, as did the specific Erk1/2 inhibitor U0126
Beswick et al., Infect Immun 2008
:
Macrophage migration inhibitory factor and
interleukin-8 produced by gastric epithelial cells during Helicobacter pylori exposure
induce expression and activation of the
epidermal growth factor receptor ... MIF and
IL-8 also
induced phosphorylation of
EGFR , signaling events, and proliferation during H. pylori exposure, all of which were decreased when they were neutralized by these cytokines or were blocked from their receptors
Boots et al., J Biol Chem 2009
:
Both ADAM17 activation and
IL-8 release were
suppressed by inhibitors of
EGFR/ERK1/2 signaling, which can regulate ADAM17 activity by serine/threonine phosphorylation
Wu et al., J Neurosurg 2010
(Brain Injuries...) :
Simvastatin modified the caveolin-1 expression in lipid rafts in astrocyte cell membrane, suppressed the phosphorylation of
EGFR in lipid rafts of astrocytes after OGD, and
inhibited the OGD induced
interleukin-1 production
Zhang et al., J Cell Physiol 2012
(Carcinoma, Non-Small-Cell Lung...) :
EGF stimulated
IL-8 production, phosphorylation of Akt and Erk, and cell proliferation and movement could be
inhibited by
EGFR inhibitor ( Erlotinib ), PI3K inhibitor ( GDC-0941 BEZ-235 and SHBM1009 ), and ERK1/2 inhibitor ( PD98059 )
Breshears et al., J Biol Chem 2012
:
EGFR signaling is
critical for up-regulation of
IL-8 at the transcriptional level in response to TSST-1 and is also necessary for AREG, TGFa, and TNFR1 shedding
Singh et al., Clin Cancer Res 2013
(Breast Neoplasms...) :
IL-8 induced activation of
EGFR/HER2 and downstream signaling pathways and effects were abrogated by inhibition of SRC, EGFR/HER2, phosphoinositide 3-kinase (PI3K), or MEK