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CRK — IL8

Text-mined interactions from Literome

Hashimoto et al., Eur Respir J 1999 : Inhibition of TNF-alpha- and IL-1alpha induced p38 MAP kinase activity by SB 203580 inhibited TNF-alpha- and IL-1alpha induced IL-8 protein production as well as IL-8 messenger ribonucleic acid ( mRNA ) expression, indicating that SB 203580 was effective at the transcriptional level
Arbabi et al., Arch Surg 1999 : Priming interleukin 8 production : role of platelet activating factor and p38
Hashimoto et al., J Pharmacol Exp Ther 2000 : Selective inhibitor of p38 mitogen activated protein kinase inhibits lipopolysaccharide induced interleukin-8 expression in human pulmonary vascular endothelial cells
Wang et al., J Biol Chem 2002 : Moreover, IL-8 mRNA stability was significantly enhanced by FVIIa induced activation of the mitogen activated protein kinases ERK1/2 and p38
Jijon et al., Am J Physiol Cell Physiol 2002 : In contrast, ERK and p38 inhibition resulted in the accelerated degradation of the IL-8 mRNA, suggesting that in HT-29 cells, p38 and ERK contribute to TNF-alpha stimulated IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism that involves stabilization of the IL-8 transcript
Furuichi et al., Respirology 2002 (Asthma, Exercise-Induced...) : We have previously shown that p38 mitogen activated protein kinase ( MAPK ) regulates, at least in part, hyperosmolarity induced interleukin (IL)-8 expression in human bronchial epithelial cells ( BEC )
Li et al., Am J Physiol Lung Cell Mol Physiol 2002 (MAP Kinase Signaling System) : Finally, inhibition of p38 attenuated IL-8 protein abundance, suggesting that p38 regulates IL-8 expression in a posttranscriptional manner
Garcia-Cao et al., EMBO Rep 2003 (MAP Kinase Signaling System) : Consistent with recent reports demonstrating the antagonistic actions of NF-kappaB and c-Jun amino-terminal kinase (JNK) signalling, we have found that Par4 ( -/- ) cells show a reduced activation of the sustained phase of JNK and p38 stimulation by TNF-alpha and interleukin 1
Li et al., Am J Physiol Lung Cell Mol Physiol 2003 (MAP Kinase Signaling System) : We exposed A549 cells, a type II-like alveolar epithelial cell line, to cyclic stretch at 20 cycles/min for 5 min-2 h. Cyclic stretch induced IL-8 protein production, IL-8 mRNA expression, and JNK activation, but only transient activation of p38 and ERK1/2
Scholz et al., Cardiovasc Res 2003 (Inflammation...) : Furthermore, the ERK 1/2 inhibitor, PD98059, and the p38 MAPK inhibitor, SB203580, markedly reduced 8-isoprostane induced IL-8 expression ( mRNA and protein ), while inhibition of NF-kappaB activation and translocation had no significant effect on IL-8 expression
Kim et al., Biochem Biophys Res Commun 2004 (MAP Kinase Signaling System) : The upregulation of IL-8 expression by IGF-II was reduced by pretreatment with inhibitors of tyrosine kinase, Src, PI3-kinase, and ERK, but not by p38
Zvalova et al., Glia 2004 : Therefore, interleukin-1beta (IL-1beta), which contributes to stroke induced brain injury and activates p38/SAPK2 , and hyperosmolarity induced by sorbitol, a potent stimulus of p38/SAPK2 in non-neuronal cells, were used to investigate a possible involvement of p38/SAPK2 in GJC modulation in mouse cultured astrocytes
Alvarez et al., J Immunol 2006 (MAP Kinase Signaling System) : When analyzing the role of these pathways on neutrophil functions, we observed that up-regulation of CD11b triggered by bacterial DNA was decreased by pharmacological inhibitors of the p38 MAPK, ERK1/2, and JNK, whereas stimulation of IL-8 release was dependent on p38 , ERK1/2, and NF-kappaB
Smith et al., Br J Pharmacol 2006 (Pneumonia) : p38 MAPK may regulate cytokine production, therefore, the effect of two p38 MAPK inhibitors, SB239063 and SD-282, on the release of TNF-alpha, GM-CSF and IL-8 from human macrophages was investigated
Wijagkanalan et al., Mol Pharmacol 2008 (Pneumonia) : DPML significantly inhibited tumor necrosis factor alpha, interleukin-1beta , and cytokine induced neutrophil chemoattractant-1 levels, suppressed neutrophil infiltration and myeloperoxidase activity, and inhibited NFkappaB and p38 mitogen activated protein kinase activation in the lung
Kobashi et al., Journal of inflammation (London, England) 2009 : The IL-8 induced-IL-8 mRNA expression was inhibited by PD98059 ( a MEK inhibitor ) or SB203580 ( a p38 MAPK inhibitor )
Cuong et al., Life Sci 2009 (Inflammation...) : Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha, interleukin (IL)-6 , and IL-12 p40, and the activation of ERK1/2 and p38
Chen et al., Vet Res 2011 : Administration of an inhibitor specific to p38 or JNK resulted in varying degrees of attenuation on ApxI induced cytokine expression, suggesting the differential regulatory roles of p38 and JNK in IL-1ß, IL-8 and TNF-a production
Kloesch et al., Immunol Lett 2012 (Arthritis, Rheumatoid...) : H ( 2 ) S-induced expression of IL-6, IL-8 and COX-2 was completely blocked by specific inhibitors of p38 and ERK1/2 MAPK and NF-?B
Wang et al., Zhonghua Gan Zang Bing Za Zhi 2011 (Carcinoma, Hepatocellular...) : p38 MAPK inhibitor ( SB203580 ) could significantly inhibit IL-8 production in a dose dependent manners ( F = 65.47, P < 0.01 ), and partially inhibited NF-kB p65 nuclear translocation in a dose dependent manner ( F=141.20, P < 0.05 )
Byun et al., Biochem Biophys Res Commun 2012 (Inflammation) : In addition, EGCG treated DCs inhibited lipopolysaccharide (LPS) induced production of pro-inflammatory cytokines ( tumor necrosis factor [TNF ] -a, interleukin [ IL]-1ß, and IL-6 ) and activation of mitogen activated protein kinases ( MAPKs ), e.g., extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38 , c-Jun N-terminal kinase (JNK), and nuclear factor ?B ( NF-?B ) p65 translocation through 67LR
Frey et al., Ann Rheum Dis 2013 (Arthritis, Psoriatic...) : Functionally, IL-36a induced the expression of IL-6 and IL-8 in FLS through p38/NFkB activation
Hashimoto et al., Am J Respir Crit Care Med 1999 (Bronchial Hyperreactivity) : SB 203580 as the specific p38 MAP kinase inhibitor inhibited hyperosmolarity induced p38 MAP kinase activation and partially inhibited hyperosmolarity induced IL-8 expression