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IL10 — MYD88
Text-mined interactions from Literome
Oshikawa et al., Biochem Biophys Res Commun 2003
(Lung Diseases) :
The results demonstrated three patterns of gene expression : the TLR2 and myeloid differentiation factor 88 (
MyD88 ) gene expressions were induced in AM in
response to lipopolysaccharide (LPS),
interleukin (IL)-1beta , or tumor necrosis factor-alpha or in the lung tissue of an LPS induced acute lung injury model ; the gene expressions of TLR1, -3, -6, CD14, and MD2 were unchanged ; and the TLR4 and TLR5 gene expressions were downregulated in AM following inflammatory stimuli
Boonstra et al., J Immunol 2006
:
Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce
IL-10 in
response to
MyD88- and TRIF dependent TLR signals, and TLR independent signals
Csóka et al., Blood 2007
:
The stimulatory effect of adenosine on E coli induced
IL-10 production did not
require toll-like receptor 4 (TLR4) or
MyD88 , but was blocked by p38 inhibition
Rad et al., Gastroenterology 2007
(Gastritis...) :
The adaptor protein
Myd88 mediates Toll-like receptor ( TLR ),
interleukin (IL)-1 , and IL-18 signaling
Leichtle et al., BMC immunology 2009
(Otitis Media) :
Activated TLRs signal via two alternative intracellular signaling molecules with differing effects ;
MyD88 ( Myeloid differentiation primary response gene 88 )
inducing primarily
interleukin expression and TRIF ( Tir-domain containing adaptor inducing interferon beta ) mediating type I interferon ( IFN ) expression
Kissner et al., Innate Immun 2011
(Disease Models, Animal...) :
Our results indicated that elevated tumor necrosis factor-a, interferon-?,
interleukin (IL)-1a/ß and IL-6 production from mouse spleen cells treated with SEB alone or in combination with lipopolysaccharide (LPS) was
regulated by
MyD88
Bosschaerts et al., PLoS Pathog 2010
(Trypanosomiasis) :
Tip-DC development during parasitic infection is regulated by
IL-10 and
requires CCL2/CCR2, IFN-gamma and
MyD88 signaling
Bankoti et al., J Immunol 2012
(Leishmaniasis, Visceral) :
B cells were able to capture parasites, which was associated with upregulation of surface IgM and
MyD88 dependent
IL-10 production
Klaas et al., J Immunol 2012
:
This was accompanied by a strong reduction in
MyD88 dependent secretion of TNF-a, IL-6, IL-12, and
IL-10
Koike et al., Immunol Lett 2012
(Pancreatitis) :
MyD88 dependent
interleukin-10 production from regulatory CD11b ( + ) Gr-1 ( high ) cells suppresses development of acute cerulein pancreatitis in mice
Bagchi et al., Cytokine 2013
:
Interleukin-10 activates Toll-like receptor 4 and
requires MyD88 for cardiomyocyte survival ...
IL-10 caused a significant increase in the expression of CD14,
MyD88 and TLR4