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GATA3 — IL10
Text-mined interactions from Literome
Shoemaker et al., J Immunol 2006
:
We showed that ectopic expression of
GATA-3 in naive primary CD4+ T cells
enhanced expression of
IL-10 by these cells and uncovered a possible mechanism for this effect ... Despite being recruited in vivo to two locations on the Il-10 locus,
GATA-3 did not
transactivate the
IL-10 promoter
Chang et al., Eur J Immunol 2007
:
In Th2 cells, expression of the cytokine
IL-10 is also
induced by
GATA-3
Umetsu et al., J Immunol 2009
:
Coexpression of Ikaros and
GATA-3 further
increases IL-10 production, showing that these two factors have an additive effect on activating Il10 expression
Notani et al., PLoS Biol 2010
:
In the presence of Dickkopf 1 (Dkk1), an inhibitor of Wnt signalling,
GATA-3 is downregulated and the expression of signature T ( H ) 2 cytokines such as IL-4,
IL-10 , and IL-13 is
reduced , indicating that Wnt signalling is essential for T ( H ) 2 differentiation